公开(公告)号：US20210401838A1

公开(公告)日：2021-12-30

申请号：US17472882

申请日：2021-09-13

申请人： Florida A&M University

发明人： Seth Y. Ablordeppey ,  Xue Y. Zhu

IPC分类号： A61K31/506 ,  A61P25/18 ,  A61K31/496

摘要： A method of treating psychosis, and the underlying antipsychotic formulation. The method includes administering a therapeutically effective amount of synthetic agents that selectively recruit β-arrestin to D2 receptors and have little-to-no binding to culprit receptors associated with weight gain and Type II diabetes. The synthetic agents can include SYA16263 and SYA16264, and/or derivatives or analogs thereof. The 1-(pyridin-2-yl)piperazine moiety was found to play a significant role in recruiting β-arrestin to D2 receptors. In other embodiments, the current invention relates to synthetic agents that are selective of D4 receptors for treatment of psychosis and erectile dysfunction. The synthetic agents can include SYA27287 and/or derivatives or analogs thereof. In all embodiments, extrapyramidal side effects are eliminated or minimized.

公开(公告)号：US11129831B2

公开(公告)日：2021-09-28

申请号：US16537193

申请日：2019-08-09

申请人： Florida A&M University

发明人： Seth Y. Ablordeppey ,  Xue Y. Zhu

IPC分类号： A61P25/18 ,  A61K31/496 ,  A61K31/506

摘要： A method of treating psychosis, and the underlying antipsychotic formulation. The method includes administering a therapeutically effective amount of synthetic agents that selectively recruit β-arrestin to D2 receptors and have little-to-no binding to culprit receptors associated with weight gain and Type II diabetes. The synthetic agents can include SYA16263 and SYA16264, and/or derivatives or analogs thereof. The 1-(pyridin-2-yl)piperazine moiety was found to play a significant role in recruiting β-arrestin to D2 receptors. In other embodiments, the current invention relates to synthetic agents that are selective of D4 receptors for treatment of psychosis and erectile dysfunction. The synthetic agents can include SYA27287 and/or derivatives or analogs thereof. In all embodiments, extrapyramidal side effects are eliminated or minimized.