公开(公告)号：US12123034B2

公开(公告)日：2024-10-22

申请号：US18447681

申请日：2023-08-10

Applicant: Flagship Pioneering Innovations VI, LLC

Inventor： Robert Charles Altshuler ,  Anne Helen Bothmer ,  Cecilia Giovanna Silvia Cotta-Ramusino ,  Randi Michelle Kotlar ,  Ananya Ray ,  Nathaniel Roquet ,  Carlos Sanchez ,  Barrett Ethan Steinberg

IPC: C12N9/22 ,  C12N9/12 ,  C12N15/10 ,  C12N15/11 ,  C12N15/90

CPC classification number: C12N9/22 ,  C12N9/1276 ,  C12N15/1082 ,  C12N15/11 ,  C12N15/907 ,  C12Y207/07049 ,  C12N2310/20 ,  C12N2800/80

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject.

公开(公告)号：US20240002886A1

公开(公告)日：2024-01-04

申请号：US18447536

申请日：2023-08-10

Applicant: Flagship Pioneering Innovations VI, LLC

Inventor： Robert Charles Altshuler ,  Anne Helen Bothmer ,  Cecilia Giovanna Silvia Cotta-Ramusino ,  Randi Michelle Kotlar ,  Ananya Ray ,  Nathaniel Roquet ,  Carlos Sanchez ,  Barrett Ethan Steinberg

IPC: C12N15/90 ,  C12N15/11 ,  C12N9/22 ,  C12N9/12 ,  C12N15/10

CPC classification number: C12N15/907 ,  C12N15/11 ,  C12N9/22 ,  C12N9/1276 ,  C12N15/1082 ,  C12N2310/20 ,  C12N2800/80

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject.

公开(公告)号：US12157898B2

公开(公告)日：2024-12-03

申请号：US18355017

申请日：2023-07-19

Applicant: Flagship Pioneering Innovations VI, LLC

Inventor： Anne Helen Bothmer ,  Cecilia Giovanna Silvia Cotta-Ramusino ,  William Edward Salomon ,  Jacob Rosenblum Rubens ,  Robert James Citorik ,  Zi Jun Wang ,  Kyusik Kim ,  Randi Michelle Kotlar ,  Ananya Ray ,  Robert Charles Altshuler ,  Sandeep Kumar ,  Nathaniel Roquet ,  Barrett Ethan Steinberg

IPC: C12N15/90 ,  C12N9/22 ,  C12N15/11 ,  C12N15/88

Abstract: Methods and compositions for modulating a target genome are disclosed. This disclosure relates to novel compositions, systems and methods for altering a genome at one or more locations in a host cell, tissue or subject, in vivo or in vitro. In particular, the invention features compositions, systems and methods for inserting, altering, or deleting sequences of interest in a host genome.

公开(公告)号：US20240084334A1

公开(公告)日：2024-03-14

申请号：US18469344

申请日：2023-09-18

Applicant: Flagship Pioneering Innovations VI, LLC

Inventor： Robert Charles Altshuler ,  Anne Helen Bothmer ,  Daniel Raymond Chee ,  Cecilia Giovanna Silvia Cotta-Ramusino ,  Kyusik Kim ,  Randi Michelle Kotlar ,  Gregory David McAllister ,  Ananya Ray ,  Nathaniel Roquet ,  Carlos Sanchez ,  Barrett Ethan Steinberg ,  William Edward Salomon ,  Robert James Citorik ,  William Querbes ,  Luciano Henrique Apponi ,  Zhan Wang

IPC: C12N15/90 ,  C07K14/81 ,  C12N9/12 ,  C12N9/22 ,  C12N15/11

CPC classification number: C12N15/907 ,  C07K14/8125 ,  C12N9/1276 ,  C12N9/22 ,  C12N15/11 ,  C12Y207/07049 ,  A61K48/00 ,  C12N2310/20

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating alpha-1 antitrypsin deficiency (AATD) are described.

公开(公告)号：US20240417757A1

公开(公告)日：2024-12-19

申请号：US18805023

申请日：2024-08-14

Applicant: Flagship Pioneering Innovations VI, LLC

Inventor： Anne Helen Bothmer ,  Cecilia Giovanna Silvia Cotta-Ramusino ,  William Edward Salomon ,  Jacob Rosenblum Rubens ,  Robert James Citorik ,  Zi Jun Wang ,  Kyusik Kim ,  Randi Michelle Kotlar ,  Ananya Ray ,  Robert Charles Altshuler ,  Sandeep Kumar ,  Nathaniel Roquet ,  Barrett Ethan Steinberg

IPC: C12N15/90 ,  C12N9/22 ,  C12N15/11 ,  C12N15/88

Abstract: Methods and compositions for modulating a target genome are disclosed.

公开(公告)号：US12024728B2

公开(公告)日：2024-07-02

申请号：US18356013

申请日：2023-07-20

Applicant: Flagship Pioneering Innovations VI, LLC

Inventor： Robert Charles Altshuler ,  Anne Helen Bothmer ,  Cecilia Giovanna Silvia Cotta-Ramusino ,  Randi Michelle Kotlar ,  Ananya Ray ,  Nathaniel Roquet ,  Carlos Sanchez ,  Barrett Ethan Steinberg

IPC: C12N9/22 ,  C12N9/12 ,  C12N15/10 ,  C12N15/11 ,  C12N15/90

CPC classification number: C12N9/22 ,  C12N9/1276 ,  C12N15/1082 ,  C12N15/11 ,  C12N15/907 ,  C12Y207/07049 ,  C12N2310/20 ,  C12N2800/80

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject.

公开(公告)号：US20240093186A1

公开(公告)日：2024-03-21

申请号：US18470687

申请日：2023-09-20

Applicant: Flagship Pioneering Innovations VI, LLC

Inventor： Robert Charles Altshuler ,  Anne Helen Bothmer ,  Daniel Raymond Chee ,  Cecilia Giovanna Silvia Cotta-Ramusino ,  Kyusik Kim ,  Randi Michelle Kotlar ,  Gregory David McAllister ,  Aamir Mir ,  Ananya Ray ,  Nathaniel Roquet ,  Carlos Sanchez ,  Barrett Ethan Steinberg ,  Robert James Citorik ,  William Edward Salomon ,  William Querbes ,  Luciano Henrique Apponi ,  Zhan Wang

IPC: C12N15/11 ,  C12N9/12 ,  C12N9/22 ,  C12N15/90

CPC classification number: C12N15/11 ,  C12N9/1276 ,  C12N9/22 ,  C12N15/111 ,  C12N15/907 ,  C12N2310/20

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating cystic fibrosis, e.g., in subjects having a mutation resulting in F508del, are described.

公开(公告)号：US20240002822A1

公开(公告)日：2024-01-04

申请号：US18356013

申请日：2023-07-20

Applicant: Flagship Pioneering Innovations VI, LLC

Inventor： Robert Charles Altshuler ,  Anne Helen Bothmer ,  Cecilia Giovanna Silvia Cotta-Ramusino ,  Randi Michelle Kotlar ,  Ananya Ray ,  Nathaniel Roquet ,  Carlos Sanchez ,  Barrett Ethan Steinberg

IPC: C12N9/22 ,  C12N9/12 ,  C12N15/11 ,  C12N15/90

CPC classification number: C12N9/22 ,  C12N9/1276 ,  C12Y207/07049 ,  C12N15/11 ,  C12N15/907 ,  C12N2310/20

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject.

公开(公告)号：US20240374759A1

公开(公告)日：2024-11-14

申请号：US18690134

申请日：2022-09-07

Applicant: Flagship Pioneering Innovations VI, LLC

Inventor： Robert Charles Altshuler ,  Anne Helen Bothmer ,  Robert James Citorik ,  Cecilia Giovanna Silvia Cotta-Ramusino ,  Kyusik Kim ,  Randi Michelle Kotlar ,  Sandeep Kumar ,  Ananya Ray ,  Nathaniel Roquet ,  Jacob Rosenblum Rubens ,  William Edward Salomon ,  Barrett Ethan Steinberg ,  Zi Jun Wang ,  Ersin Akinci

IPC: A61K48/00 ,  C12N9/22 ,  C12N15/11

Abstract: Methods and compositions for modulating a target genome are disclosed.

公开(公告)号：US20240252682A1

公开(公告)日：2024-08-01

申请号：US18590275

申请日：2024-02-28

Applicant: Flagship Pioneering Innovations VI, LLC

Inventor： Robert Charles Altshuler ,  Anne Helen Bothmer ,  Daniel Raymond Chee ,  Cecilia Giovanna Silvia Cotta-Ramusino ,  Kyusik Kim ,  Randi Michelle Kotlar ,  Gregory David McAllister ,  Ananya Ray ,  Nathaniel Roquet ,  Carlos Sanchez ,  Barrett Ethan Steinberg ,  William Edward Salomon ,  Robert James Citorik ,  William Querbes ,  Luciano Henrique Apponi ,  Zhan Wang ,  Yanfang Fu ,  Daniel Gene Abernathy ,  Michael Christopher Holmes

IPC: A61K48/00 ,  A61P7/06 ,  C12N9/22 ,  C12N15/11 ,  C12N15/85

CPC classification number: A61K48/005 ,  A61P7/06 ,  C12N9/22 ,  C12N15/111 ,  C12N15/85 ,  C12N2310/20

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating sickle cell disease (SCD) are described.