知搜-全球专利检索

  1. Login
  2. Sign Up

Search Results

6 records (took 0.026 seconds)

    Method of identifying malodor modulating compounds
    1.
    发明授权
    Method of identifying malodor modulating compounds 有权

    公开(公告)号：US11787847B2

    公开(公告)日：2023-10-17

    申请号：US16492115

    申请日：2018-03-08

    Applicant: FIRMENICH SA

    Inventor： Patrick Pfister ,  Matthew Rogers ,  Huey-Ling Kao ,  Claude Ayome Abibi

    IPC: C07K14/705 ,  G01N33/50

    CPC classification number: C07K14/705 ,  G01N33/5008 ,  G01N2500/20

    Abstract: Provided herein are polypeptides that bind to the malodour-causing substance DMTS. Also provided are nucleic acid sequences that encode for the polypeptides. Further provided herein is a method for identifying a compound that binds, suppresses, blocks, inhibits, and/or modulates the activity of one or more olfactory receptor that is activated by the malodor-causing substance DMTS comprising a) contacting the receptor, or a chimera or fragment thereof with a compound and b) determining whether the compound has an effect on the activity of the receptor. Further provided is an expression vector comprising the nucleic acid encoding the polypeptides described as well as a non-human organism or a host cell modified to express a receptor that is activated by DMTS. Also provided is the use of the polypeptides for identifying malodor modulating compounds.

    METHOD OF IDENTIFYING MALODOR MODULATING COMPOUNDS
    2.
    发明公开
    METHOD OF IDENTIFYING MALODOR MODULATING COMPOUNDS 审中-公开

    公开(公告)号：US20240117001A1

    公开(公告)日：2024-04-11

    申请号：US18486417

    申请日：2023-10-13

    Applicant: FIRMENICH SA

    Inventor： Patrick Pfister ,  Matthew Rogers ,  Huey-Ling Kao ,  Claude Ayome Abibi

    IPC: C07K14/705 ,  G01N33/50

    CPC classification number: C07K14/705 ,  G01N33/5008 ,  G01N2500/20

    Abstract: Provided herein are polypeptides that bind to the malodour-causing substance DMTS. Also provided are nucleic acid sequences that encode for the polypeptides. Further provided herein is a method for identifying a compound that binds, suppresses, blocks, inhibits, and/or modulates the activity of one or more olfactory receptor that is activated by the malodor-causing substance DMTS comprising a) contacting the receptor, or a chimera or fragment thereof with a compound and b) determining whether the compound has an effect on the activity of the receptor. Further provided is an expression vector comprising the nucleic acid encoding the polypeptides described as well as a non-human organism or a host cell modified to express a receptor that is activated by DMTS. Also provided is the use of the polypeptides for identifying malodor modulating compounds.

    Malodor counteracting ingredients
    3.
    发明授权
    Malodor counteracting ingredients 有权

    公开(公告)号：US11168283B2

    公开(公告)日：2021-11-09

    申请号：US16761693

    申请日：2018-11-21

    Applicant: Firmenich SA

    Inventor： Huey-Ling Kao ,  Stefan Alexander Ruider ,  Steven Williams ,  Anthony Alexander Birkbeck

    IPC: C11B9/00 ,  G01N33/566

    Abstract: The various aspects presented herein relate to the perfumery industry. More particularly, the various aspects presented herein relate to malodor counteracting compositions and/or ingredients, methods for counteracting malodors, as well as to the perfumed articles or perfuming compositions comprising as an active ingredient, at least one compound selected 5 from the group consisting of: 1-(2-methyl-4-tricyclo[5.2.1.01,5]decanyl)ethyl acetate, 1-(2,4-di-methyl-4-tricyclo[5.2.1.01,5]decanyl)ethyl acetate, 1-((1R,3S,3aS,6S)-1,2,3-trimethyloctahydro-3a,6-methanoinden-1-yl)ethan-1-one, 1-(2,4-dimethyl-4-tricyclo[5.2.1.0{circumflex over ( )}{1,5}]decanyl)ethanone, 2,3,4-trimethyltricyclo[5.2.1.0{circumflex over ( )}{1,5}]decane-4-carbaldehyde, (2,3,4-trimethyl-4-tricyclo[5.2.1.0{circumflex over ( )}{1,5}]decanyl)methyl acetate, 1-((3aS,6S)-10 2,3-dimethyloctahydro-3a,6-methanoinden-1-yl)ethan-1-one oxime, 1,3-dimethyloctahydro-3a,6-methanoindene-1-carbaldehyde oxime, ˜{N}-[1-[(1˜{R},7˜{R})-2,3,4-trimethyl-4-tricyclo[5.2.1.01,5]decanyl]ethylidene]hydroxylamine, (+−)-1-(2,4-dimethyltricyclo[5.2.1.01,5]dec-4-yl) ethanone, (+−)-1-(2,4-dimethyltricyclo[5.2.1.0˜1.5˜]dec-4-yl) ethyl acetate, 1-[(1RS,2RS,4SR,7RS)-2,3,4-trimethyltricyclo[5.2.1.01.˜]dec-4-yl) 15 ethanone, (E/Z)-1-[(1RS,7RS)-2,3-dimethyltricyclo[5.2.1.01,5]dec-4-yl) ethanone oxime, (E/Z)-1-[(1S,7S)-2,3,4-trimethyltricyclo[5.2.1.0˜1.5˜]dec-4-yl) ethanone oxime, (E/Z)-1-((3aS,6S)-1,2,3-trimethyloctahydro-3a,6-methanoinden-1-yl)ethanone oxime, (+−)-1-(3-methyloctahydro-3a,6-methanoinden-1-yl)ethyl acetate, and mixtures thereof.

    METHOD OF IDENTIFYING MALODOR MODULATING COMPOUNDS
    6.
    发明申请
    METHOD OF IDENTIFYING MALODOR MODULATING COMPOUNDS 审中-公开

    公开(公告)号：US20200002399A1

    公开(公告)日：2020-01-02

    申请号：US16492115

    申请日：2018-03-08

    Applicant: FIRMENICH SA

    Inventor： Patrick Pfister ,  Matthew Rogers ,  Huey-Ling Kao ,  Claude Ayome Abibi

    IPC: C07K14/705 ,  G01N33/50

    Abstract: Provided herein are polypeptides that bind to the malodour-causing substance DMTS. Also provided are nucleic acid N sequences that encode for the polypeptides. Further provided herein is a method for identifying a compound that binds, suppresses, blocks, inhibits, and/or modulates the activity of one or more olfactory receptor that is activated by the malodor-causing substance DMTS comprising a) contacting the receptor, or a chimera or fragment thereof with a compound and b) determining whether the compound has an effect on the activity of the receptor. Further provided is an expression vector comprising the nucleic acid encoding the polypeptides described as well as a non-human organism or a host cell modified to express a receptor that is activated by DMTS. Also provided is the use of the polypeptides for identifying malodor modulating compounds.

Patent Agency Ranking