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公开(公告)号：US20240010987A1
公开(公告)日：2024-01-11
申请号：US18038444
申请日：2021-11-24
发明人： Seong Wook SEO , Yoon Pyo CHOI , Sang Yeop AHN , Da In PARK , Myeong Hoon LEE
CPC分类号： C12N5/067 , C12M29/04 , C12N2503/00 , C12N2502/1157
摘要： The present invention relates to an in vitro liver disease model using triple co-culture and a preparation method thereof, and the method of preparing the in vitro liver disease model includes directly co-culturing hepatocytes and hepatic stellate cells, and simultaneously indirectly co-culturing Kupffer cells by being separated from the hepatocytes and the hepatic stellate cells to enable a rapid and highly accurate analysis by similarly implementing the in vivo environment compared to mono-culture, and simultaneously make it easier to collect and measure specimens than typical direct co-culture.
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2.发明公开公开(公告)号：US20240148769A1
公开(公告)日：2024-05-09
申请号：US18277982
申请日：2022-02-17
发明人： Hyuk Woo LEE , Seo Hyun SON , Ji Yoon KANG , Hyu Jeong JANG , Seong Wook SEO
IPC分类号： A61K31/7076 , A61P31/14
CPC分类号： A61K31/7076 , A61P31/14
摘要： The present invention relates to a pharmaceutical composition for preventing or treating coronavirus disease 19 (COVID-19) and specifically, to a pharmaceutical composition containing a carbocyclic nucleoside derivative represented by Chemical Formula A-1 or A-2 or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20240325399A1
公开(公告)日：2024-10-03
申请号：US18578736
申请日：2022-01-25
发明人： Hyuk Woo LEE , Sang Yeop AHN , Hyeon Deok CHO , Yoon Pyo CHOI , Seong Wook SEO
CPC分类号： A61K31/52 , A61K9/4866 , A61P1/16
摘要： The present invention relates to a pharmaceutical composition comprising an adenosine derivative which can be usefully used for preventing or treating cholangitis or a liver disease caused by cholangitis, and the composition comprises a compound represented by Chemical Formula 1 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
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