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公开(公告)号：US11951092B2
公开(公告)日：2024-04-09
申请号：US16617739
申请日：2018-06-01
IPC分类号： A61K31/397 , A61K9/00 , A61P25/28
CPC分类号： A61K31/397 , A61K9/0053 , A61P25/28
摘要： An object of the present invention is to provide a drug which prevents progress of Alzheimer's disease and a method of preventing progress of Alzheimer's disease. 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof has an effect of suppressing brain atrophy and is useful as an agent for preventing or treating brain atrophy. Brain atrophy observed in aging or neurodegenerative diseases can be prevented or treated by administering 1-(3-(2-(1-Benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof.
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公开(公告)号：US11666551B2
公开(公告)日：2023-06-06
申请号：US16617607
申请日：2018-06-01
IPC分类号： A61K31/397 , A61K9/00 , A61P25/28
CPC分类号： A61K31/397 , A61K9/0053 , A61P25/28
摘要： An object of the present invention is to provide a drug and a method which suppress progress of disease in which the amount of amyloid β protein in the brain is increased, such as Alzheimer's disease. 1-(3-(2-(1-Benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof has an effect of reducing the amount of amyloid β protein in the brain parenchyma, and thus is effective as an agent for reducing the amount of amyloid β protein in the brain. Disease in which the amount of amyloid β protein in the brain is increased, such as Alzheimer's disease, can be prevented or treated by administering 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof.
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公开(公告)号：US11660287B2
公开(公告)日：2023-05-30
申请号：US16617660
申请日：2018-06-01
IPC分类号： A61K31/397 , A61P25/28
CPC分类号： A61K31/397 , A61P25/28
摘要： An object of the present invention is to provide an excellent drug for preventing or treating spinocerebellar ataxia. 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof has an effect of suppressing brain atrophy, especially cerebellar atrophy, and is useful as an agent for preventing or treating spinocerebellar ataxia. Cerebellar atrophy observed in spinocerebellar ataxia can be prevented or treated by administering 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof.
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公开(公告)号：US11541033B2
公开(公告)日：2023-01-03
申请号：US16617584
申请日：2018-06-01
IPC分类号： A61K31/397 , A61P25/28 , A61K9/00
摘要： An object of the present invention is to provide a drug which prevents progress of Alzheimer's disease and a method of preventing progress of Alzheimer's disease. Alzheimer's disease can be effectively prevented or treated by initiating administration of a pharmaceutical composition comprising 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof as an active ingredient to a patient within a certain period from clinical diagnosis of Alzheimer's disease.
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公开(公告)号：US11344530B2
公开(公告)日：2022-05-31
申请号：US16617660
申请日：2018-06-01
IPC分类号： A61K31/397 , A61P25/28
摘要： An object of the present invention is to provide an excellent drug for preventing or treating spinocerebellar ataxia. 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof has an effect of suppressing brain atrophy, especially cerebellar atrophy, and is useful as an agent for preventing or treating spinocerebellar ataxia. Cerebellar atrophy observed in spinocerebellar ataxia can be prevented or treated by administering 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof.
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