公开(公告)号：US20160311934A1

公开(公告)日：2016-10-27

申请号：US14777908

申请日：2014-03-20

Applicant: FRESENIUS KABI DEUTSCHLAND GMBH

Inventor： Norbert ZANDER ,  Sabrina HUMMEL ,  Ulrike WEDEMEYER ,  Thomas HEY ,  Dominik HECKMANN

IPC: C08B31/12 ,  A61K38/17 ,  C12N9/90 ,  A61K38/52 ,  A61K38/38 ,  C12N9/96 ,  A61K47/48 ,  A61K38/57

CPC classification number: C08B31/125 ,  A61K38/1709 ,  A61K38/1793 ,  A61K38/385 ,  A61K38/52 ,  A61K38/57 ,  A61K47/61 ,  C12N9/90 ,  C12N9/96 ,  C12Y502/01008

Abstract: The present invention relates to a hydroxyalkyl starch (HAS) derivative of formula (I) wherein F1 is a functional group comprising the group —NR′—, with R′ being H or alkyl; L is a spacer bridging F1 and S; wherein HAS′ is the remainder of the HAS molecule, Rb and Rc are —[(CR1R2)mO]n—H and are the same or different from each other; Ra is —[(CR1R2)mO]n—H with HAS′ being the remainder of the hydroxyalkyl starch molecule, or Ra is HAS″ with HAS′ and HAS″ together being the remainder of the hydroxyalkyl starch molecule; R1 and R2 are independently hydrogen or an alkyl group having from 1 to 4 carbon atoms, m is 2 to 4, wherein R1 and R2 are the same or different from each other in the m groups CR1R2; n is from 0 to 6.