公开(公告)号：US20230416382A1

公开(公告)日：2023-12-28

申请号：US18248979

申请日：2021-10-13

Applicant: Five Prime Therapeutics, Inc.

Inventor： Susannah D. BARBEE ,  Shujun YUAN ,  Marcel MEURY ,  Alessandro PALUMBO ,  Terence WONG ,  Kathrin ZUBERBUHLER ,  Emilia FALKOWSKA

IPC: C07K16/28 ,  A61P35/00

CPC classification number: C07K16/2866 ,  A61P35/00 ,  C07K2317/565

Abstract: This present invention provides anti-C—C chemokine type 8 (CCR8) antibodies and antigen binding fragments thereof, methods of making the antibodies or antigen binding fragments thereof, and methods of use thereof to bind to human CCR8 on CCR8 expressing cells, e.g., tumor-infiltrating Treg cells, to remove CCR8 expressing cells, e.g, tumor-infiltrating Treg cells, to reduce or inhibit tumor growth and/or to treat cancer.

公开(公告)号：US20220031806A1

公开(公告)日：2022-02-03

申请号：US17432640

申请日：2020-02-21

Applicant: FIVE PRIME THERAPEUTICS, INC.

Inventor： Susannah D. BARBEE ,  Thomas BRENNAN ,  Barbara SENNINO

IPC: A61K38/17 ,  G01N33/574 ,  A61P35/00

Abstract: The present disclosure provides methods of treating PD-L1 negative tumors, the methods comprising administering fusion proteins comprising the extracellular domain of human cluster of differentiation 80 (CD80) and the fragment crystallizable (Fc) domain of human immunoglobulin G 1 (IgG1).

公开(公告)号：US20210340214A1

公开(公告)日：2021-11-04

申请号：US17271792

申请日：2019-08-28

Applicant: FIVE PRIME THERAPEUTICS, INC.

Inventor： Sandeep P. INAMDAR ,  Kristen PIERCE ,  Hong XIANG ,  Susannah D. BARBEE

IPC: C07K14/705 ,  A61P35/00 ,  A61K9/00 ,  A61K31/7012 ,  C07K16/18

Abstract: The present disclosure provides methods of administering fusion proteins comprising the extracellular domain of human cluster of differentiation 80 (CD80) and the fragment crystallizable (Fc) domain of human immunoglobulin G 1 (IgG1) to a subject in need thereof, for example, a cancer patient.

公开(公告)号：US20200182858A1

公开(公告)日：2020-06-11

申请号：US16608911

申请日：2018-04-27

Applicant: Five Prime Therapeutics, Inc.

Inventor： Thomas BRENNAN ,  Barbara SENNINO ,  Susannah D. BARBEE ,  Ursula JEFFRY

IPC: G01N33/50 ,  G01N15/10

Abstract: This application relates to use of CD80 (B7-1) extracellular domain (ECD) polypeptides and CD80-ECD fusion molecules and their use in methods of increasing the number of central memory T cells or for treatment for cancer or for use in cancer vaccine compositions.