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公开(公告)号：US20240277704A1
公开(公告)日：2024-08-22
申请号：US18643253
申请日：2024-04-23
申请人： Eye Therapies LLC
发明人： Gerald Horn
CPC分类号： A61K31/498 , A61K9/0019 , A61K9/0048 , A61K9/0073 , A61K9/08 , A61K47/10 , A61K47/26 , A61K47/40 , A61P27/02
摘要： The invention generally relates to compositions for inducing vasoconstriction. The compositions comprise highly selective alpha-2 adrenergic receptor agonists, at low concentrations, such as below 0.05% weight by volume. The compositions preferably comprise brimonidine. The compositions preferably have pH from about 4.0 to about 7.5.
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公开(公告)号：US11833245B2
公开(公告)日：2023-12-05
申请号：US18103404
申请日：2023-01-30
申请人： Eye Therapies, LLC
发明人： Gerald Horn
CPC分类号： A61K9/0048 , A61K9/0043 , A61K9/08 , A61K31/44 , A61K31/498 , A61K45/06 , A61K31/498 , A61K2300/00
摘要： The invention generally relates to compositions for inducing vasoconstriction. The compositions comprise highly selective alpha-2 adrenergic receptor agonists, at low concentrations, such as below 0.05% weight by volume. The compositions preferably comprise brimonidine. The compositions preferably have pH between about 5.5 and about 6.5.
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公开(公告)号：US20210369706A1
公开(公告)日：2021-12-02
申请号：US17405773
申请日：2021-08-18
申请人： Eye Therapies, LLC
发明人： Gerald Horn
IPC分类号： A61K31/498 , A61K31/5575 , A61P27/06 , A61K47/18 , A61K9/00 , A61K47/26
摘要： The present invention is directed to compositions containing low-dose brimonidine and a second glaucoma drug. The present invention is further directed to methods of treating glaucoma by administering compositions of the present invention.
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公开(公告)号：US20210259962A1
公开(公告)日：2021-08-26
申请号：US17318562
申请日：2021-05-12
申请人： Eye Therapies, LLC
发明人： Gerald Horn
IPC分类号： A61K9/00 , A61K31/498 , A61K47/26 , A61K47/38 , A61K47/10 , A61P27/06 , A61K47/12 , A61K47/34 , A61K47/40 , A61K47/44 , A61K47/18 , A61K47/02
摘要： The present invention is directed to methods for improving night vision and visual performance in low light conditions comprising ophthalmological administration of compositions comprising low dose brimonidine and a vehicle for improved performance.
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公开(公告)号：US20150119401A1
公开(公告)日：2015-04-30
申请号：US14593235
申请日：2015-01-09
申请人： Eye Therapies, LLC
发明人： Gerald Horn
IPC分类号： A61K31/498 , A61K47/32 , A61K47/38
CPC分类号： A61K31/498 , A61K9/0043 , A61K9/0048 , A61K9/08 , A61K47/10 , A61K47/32 , A61K47/38
摘要： The invention provides compositions and methods for treating nasal congestion. The provided compositions and methods utilize low concentrations of selective a-2 adrenergic receptor agonists. The compositions preferably include brimonidine.
摘要翻译： 本发明提供治疗鼻充血的组合物和方法。 所提供的组合物和方法利用低浓度的选择性α-2肾上腺素能受体激动剂。 组合物优选包括溴莫尼定。
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公开(公告)号：US08952011B2
公开(公告)日：2015-02-10
申请号：US14010340
申请日：2013-08-26
申请人： Eye Therapies, LLC
发明人： Gerald Horn
IPC分类号： A01N43/58 , A01N43/60 , A61K31/50 , A61K31/495 , A61K31/498 , A61K9/00 , A61K9/08 , A61K47/10 , A61K47/32 , A61K47/38
CPC分类号： A61K31/498 , A61K9/0043 , A61K9/0048 , A61K9/08 , A61K47/10 , A61K47/32 , A61K47/38
摘要： The invention provides compositions and methods for treating nasal congestion. The provided compositions and methods utilize low concentrations of selective α-2 adrenergic receptor agonists. The compositions preferably include brimonidine.
摘要翻译： 本发明提供治疗鼻充血的组合物和方法。 所提供的组合物和方法利用低浓度的选择性α-2肾上腺素能受体激动剂。 组合物优选包括溴莫尼定。
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公开(公告)号：US20140038973A1
公开(公告)日：2014-02-06
申请号：US14044929
申请日：2013-10-03
申请人： Eye Therapies, LLC
发明人： Gerald Horn
IPC分类号： A61K31/498
CPC分类号： A61K31/498 , A61K9/0048 , A61K9/08 , A61K31/165 , A61K31/198 , A61K31/4168 , A61K31/4174 , A61K31/4178 , A61K45/06 , A61K33/14 , A61K2300/00 , A61K33/20
摘要： The invention provides compositions and methods for whitening of eyes. The provided compositions and methods utilize low concentrations of selective α-2 adrenergic receptor agonists. The compositions preferably include brimonidine.
摘要翻译： 本发明提供了眼睛美白的组合物和方法。 所提供的组合物和方法利用低浓度的选择性α-2肾上腺素能受体激动剂。 组合物优选包括溴莫尼定。
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公开(公告)号：US20190269681A1
公开(公告)日：2019-09-05
申请号：US16395547
申请日：2019-04-26
申请人： Eye Therapies, LLC
发明人： Gerald Horn
摘要： The invention generally relates to compositions for inducing vasoconstriction. The compositions comprise highly selective alpha-2 adrenergic receptor agonists, at low concentrations, such as below 0.05% weight by volume. The compositions preferably comprise brimonidine. The compositions preferably have pH from about 4.0 to about 7.5.
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公开(公告)号：US20180369240A1
公开(公告)日：2018-12-27
申请号：US16119592
申请日：2018-08-31
申请人： Eye Therapies LLC
发明人： Gerald Horn
IPC分类号： A61K31/498 , A61K9/00 , A61P27/02
摘要： The invention generally relates to compositions and methods for preferential vasoconstriction of smaller blood vessels relative to larger blood vessels. The compositions comprise highly selective alpha-2 adrenergic receptor agonists, at low concentrations, such as below 0.05% weight by volume. The compositions preferably comprise brimonidine. The compositions preferably have pH between about 5.5 and about 6.5.
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公开(公告)号：US09259425B2
公开(公告)日：2016-02-16
申请号：US14044929
申请日：2013-10-03
申请人： Eye Therapies, LLC
发明人： Gerald Horn
IPC分类号： A61K31/498 , A61K9/00 , A61K9/08 , A61K45/06 , A61K31/165 , A61K31/198 , A61K31/4168 , A61K31/4174 , A61K31/4178
CPC分类号： A61K31/498 , A61K9/0048 , A61K9/08 , A61K31/165 , A61K31/198 , A61K31/4168 , A61K31/4174 , A61K31/4178 , A61K45/06 , A61K33/14 , A61K2300/00 , A61K33/20
摘要： The invention provides compositions and methods for whitening of eyes. The provided compositions and methods utilize low concentrations of selective α-2 adrenergic receptor agonists. The compositions preferably include brimonidine.
摘要翻译： 本发明提供了眼睛美白的组合物和方法。 所提供的组合物和方法利用低浓度的选择性α-2肾上腺素能受体激动剂。 组合物优选包括溴莫尼定。
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