公开(公告)号：US5539087A

公开(公告)日：1996-07-23

申请号：US444808

申请日：1995-05-18

Applicant: Ermenegildo Restelli ,  Luigia Mainoli

Inventor： Ermenegildo Restelli ,  Luigia Mainoli

IPC: C12P21/00 ,  C07K1/14 ,  C07K1/36 ,  C07K11/00 ,  C07K14/195 ,  C07K14/41 ,  C12P21/02 ,  C12R1/045 ,  A61K38/12 ,  C07K1/30 ,  C12P21/04

CPC classification number: C07K11/00 ,  C07K1/36

Abstract: The present invention is directed to a process for recovering the antibiotics produced by fermentation of Actinoplanes sp. ATCC 33076 or a producing mutant thereof, from a fermentation broth or a process stream, which comprises extraction of the antibiotics by a non-ionic surfactant or a cationic surfactant miscible with or dispersable in water and capable of dissolving the antibiotics, formation of two phases in the first of which the antibiotic and the surfactant are present together, and separation of the antibiotic from the surfactant by addition of suitable organic solvents.

Abstract translation: 本发明涉及一种回收由Actinoplanes sp。发酵生产的抗生素的方法。 ATCC 33076或其产生的突变体，其包括通过非离子表面活性剂或与水混溶或可分散在水中并能够溶解抗生素的非离子表面活性剂或阳离子表面活性剂提取抗生素，形成两相 其中首先将抗生素和表面活性剂一起存在，并通过加入合适的有机溶剂将抗生素与表面活性剂分离。