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公开(公告)号：US20190177320A1
公开(公告)日：2019-06-13
申请号：US16210472
申请日：2018-12-05
发明人： Yao-Ling Qiu , Xuri Gao , Xiaowen Peng , Wei Li , Jorden Kass , Hui Cao , Byung-Chul Suh , Yat Sun Or
IPC分类号： C07D471/10 , A61P31/14 , C07D471/04 , C07D471/20
CPC分类号： C07D471/10 , A61K45/06 , A61P31/14 , C07D471/04 , C07D471/20
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof: which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
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公开(公告)号：US11760755B2
公开(公告)日：2023-09-19
申请号：US16892373
申请日：2020-06-04
发明人： Yao-Ling Qiu , Xiaowen Peng , Xuri Gao , Wei Li , Hui Cao , Byung-Chul Suh , Jorden Kass , Jiajun Zhang , Yat Sun Or
IPC分类号： C07D453/00 , C07D487/04 , C07D519/00 , A61P31/20 , A61K38/21 , A61K31/5383 , A61K45/06 , A61K31/519
CPC分类号： C07D453/00 , A61K31/519 , A61K31/5383 , A61K38/21 , A61K45/06 , A61P31/20 , C07D487/04 , C07D519/00
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof:
which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.-
公开(公告)号：US20220402926A1
公开(公告)日：2022-12-22
申请号：US17719920
申请日：2022-04-13
发明人： Jiajun Zhang , Xiaowen Peng , Byung-Chul Suh , Jorden Kass , Xuri Gao , Hui Cao , Wei Li , Joseph D. Panarese , Guoqiang Wang , Yat Sun Or
IPC分类号： C07D487/14
摘要： The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US11236111B2
公开(公告)日：2022-02-01
申请号：US16891401
申请日：2020-06-03
发明人： Yao-Ling Qiu , Xuri Gao , Xiaowen Peng , Wei Li , Jorden Kass , Hui Cao , Byung-Chul Suh , Jiajun Zhang , Yat Sun Or
IPC分类号： C07D487/20 , C07D498/20 , A61K45/06
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof: which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
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公开(公告)号：US11596611B2
公开(公告)日：2023-03-07
申请号：US17166046
申请日：2021-02-03
发明人： Yao-Ling Qiu , Xuri Gao , Jorden Kass , Hui Cao , Wei Li , Xiaowen Peng , Byung-Chul Suh , Yat Sun Or
IPC分类号： A61K31/167 , A61K31/4164 , A61K31/34 , A61K31/357 , A61K31/4409 , A61K31/426 , A61K31/4015 , A61K31/4439 , A61K31/415 , A61K31/421 , A61K31/4192 , A61K31/351 , A61K31/397 , A61K31/337 , A61K31/47 , A61K31/513 , A61K31/7028 , A61P31/20 , A61K31/401 , C07C303/00 , C07C317/44 , A61K45/06
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: X-A-Y-L-R (I) which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
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公开(公告)号：US20230241012A1
公开(公告)日：2023-08-03
申请号：US18101258
申请日：2023-01-25
发明人： Yao-Ling Qiu , Xuri Gao , Jorden Kass , Hui Cao , Wei Li , Xiaowen Peng , Byung-Chul Suh , Yat Sun Or
IPC分类号： A61K31/167 , A61K31/4164 , A61K31/34 , A61K31/357 , A61K31/4409 , A61K31/426 , A61K31/4015 , A61K31/4439 , A61K31/415 , A61K31/421 , A61K31/4192 , A61K31/351 , A61K31/397 , A61K31/337 , A61K31/47 , A61K31/513 , A61K31/7028 , A61P31/20 , A61K31/401 , C07C303/00 , C07C317/44
CPC分类号： A61K31/167 , A61K31/4164 , A61K31/34 , A61K31/357 , A61K31/4409 , A61K31/426 , A61K31/4015 , A61K31/4439 , A61K31/415 , A61K31/421 , A61K31/4192 , A61K31/351 , A61K31/397 , A61K31/337 , A61K31/47 , A61K31/513 , A61K31/7028 , A61P31/20 , A61K31/401 , C07C303/00 , C07C317/44 , A61K45/06
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof:
X-A-Y-L-R (I)
which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.-
公开(公告)号：US10952978B2
公开(公告)日：2021-03-23
申请号：US16114842
申请日：2018-08-28
发明人： Yao-Ling Qiu , Xuri Gao , Jorden Kass , Hui Cao , Wei Li , Xiaowen Peng , Byung-Chul Suh , Yat Sun Or
IPC分类号： A61K31/167 , A61K31/4164 , A61K31/34 , A61K31/357 , A61K31/4409 , A61K31/426 , A61K31/4015 , A61K31/4439 , A61K31/415 , A61K31/421 , A61K31/4192 , A61K31/351 , A61K31/397 , A61K31/337 , A61K31/47 , A61K31/513 , A61K31/7028 , A61P31/20 , A61K31/401 , C07C303/00 , C07C317/44 , A61K45/06
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: X-A-Y-L-R (I) which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
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公开(公告)号：US10729688B2
公开(公告)日：2020-08-04
申请号：US16365742
申请日：2019-03-27
发明人： Yao-Ling Qiu , Jorden Kass , Byung-Chul Suh , Hui Cao , Wei Li , Xiaowen Peng , Xuri Gao , Yat Sun Or
IPC分类号： A61K31/4985 , C07D487/04 , A61K31/7105 , A61K45/06
摘要： The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
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公开(公告)号：US20190321360A1
公开(公告)日：2019-10-24
申请号：US16365742
申请日：2019-03-27
发明人： Yao-Ling Qiu , Jorden Kass , Byung-Chul Suh , Hui Cao , Wei Li , Xiaowen Peng , Xuri Gao , Yat Sun Or
IPC分类号： A61K31/4985 , A61K45/06 , A61K31/7105 , C07D487/04
摘要： The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
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公开(公告)号：US20190060258A1
公开(公告)日：2019-02-28
申请号：US16114842
申请日：2018-08-28
发明人： Yao-Ling Qiu , Xuri Gao , Jorden Kass , Hui Cao , Wei Li , Xiaowen Peng , Byung-Chul Suh , Yat Sun Or
IPC分类号： A61K31/167 , A61K31/401 , A61K31/4164 , A61K31/34 , A61K31/357 , A61K31/4409 , A61K31/426 , A61K31/4015 , A61K31/4439 , A61K31/415 , A61K31/421 , A61K31/4192 , A61K31/351 , A61K31/397 , A61K31/337 , A61K31/47 , A61K31/513 , A61K31/7028 , A61P31/20
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: X-A-Y-L-R (I) which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
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