公开(公告)号：US11963972B2

公开(公告)日：2024-04-23

申请号：US16088017

申请日：2017-03-22

申请人： Emory University

发明人： Raymond F. Schinazi ,  Franck Amblard ,  Bryan D. Cox ,  Leda Bassit ,  Longhu Zhou ,  Christina Gavegnano

IPC分类号： A01N43/04 ,  A61K31/4706 ,  A61K31/53 ,  A61K31/655 ,  A61K31/70 ,  A61K31/7064 ,  A61K31/7068 ,  A61P31/14

CPC分类号： A61K31/7068 ,  A61K31/4706 ,  A61K31/53 ,  A61K31/655 ,  A61K31/7064 ,  A61P31/14

摘要： The present invention is directed to compounds, compositions and methods for treating or preventing Zika virus. The compounds include pyrimidine and purine nucleosides and prodrugs thereof, including certain N4-hydroxycytidine nucleoside derivatives, sulfasalazine, and various entry inhibitors.

公开(公告)号：US20170137401A1

公开(公告)日：2017-05-18

申请号：US15311573

申请日：2015-05-15

申请人： Emory University

发明人： Bryan D. Cox ,  Lawrence J. Wilson ,  Anthony Prosser ,  Dennis C. Liotta ,  James P. Snyder

IPC分类号： C07D401/04 ,  A61K31/496 ,  A61K31/4155 ,  A61K31/4545 ,  A61K31/454 ,  C07D403/04 ,  C07D417/12 ,  C07D401/14

CPC分类号： C07D401/04 ,  A61K31/4155 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K45/06 ,  C07D401/06 ,  C07D401/14 ,  C07D403/04 ,  C07D417/12 ,  C07D417/14

摘要： The disclosure relates to chemokine receptor modulators and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising compounds disclosed herein or pharmaceutically acceptable salts or prodrugs thereof. In certain embodiments, the compositions disclosed herein are used for managing chemokine related conditions, typically prevention or treatment of viral infections such as HIV or for managing cancer.

公开(公告)号：US20240216414A1

公开(公告)日：2024-07-04

申请号：US18603143

申请日：2024-03-12

申请人： Emory University

发明人： Raymond F. Schinazi ,  Franck Amblard ,  Bryan D. Cox ,  Leda Bassit ,  Longhu Zhou ,  Christina Gavegnano

IPC分类号： A61K31/7068 ,  A61K31/4706 ,  A61K31/53 ,  A61K31/655 ,  A61K31/7064 ,  A61P31/14

CPC分类号： A61K31/7068 ,  A61K31/4706 ,  A61K31/53 ,  A61K31/655 ,  A61K31/7064 ,  A61P31/14

摘要： The present invention is directed to compounds, compositions and methods for treating or preventing Zika virus. The compounds include pyrimidine and purine nucleosides and prodrugs thereof, including certain N4-hydroxycytidine nucleoside derivatives, sulfasalazine, and various entry inhibitors.

公开(公告)号：US20230000893A1

公开(公告)日：2023-01-05

申请号：US16088017

申请日：2017-03-22

申请人： Emory University

发明人： Raymond F. Schinazi ,  Franck Amblard ,  Bryan D. Cox ,  Leda Bassit ,  Longhu Zhou ,  Christina Gavegnano

IPC分类号： A61K31/7068 ,  A61K31/655 ,  A61K31/4706 ,  A61K31/7064 ,  A61K31/53 ,  A61P31/14

摘要： The present invention is directed to compounds, compositions and methods for treating or preventing Zika virus. The compounds include pyrimidine and purine nucleosides and prodrugs thereof, including certain N4-hydroxycytidine nucleoside derivatives, sulfasalazine, and various entry inhibitors.

公开(公告)号：US10450293B2

公开(公告)日：2019-10-22

申请号：US15311573

申请日：2015-05-15

申请人： Emory University

发明人： Bryan D. Cox ,  Lawrence J. Wilson ,  Anthony Prosser ,  Dennis C. Liotta ,  James P. Snyder

IPC分类号： A61K31/4155 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K45/06 ,  C07D401/04 ,  C07D401/14 ,  C07D401/06 ,  C07D403/04 ,  C07D417/14 ,  C07D417/12

摘要： The disclosure relates to chemokine receptor modulators and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising compounds disclosed herein or pharmaceutically acceptable salts or prodrugs thereof. In certain embodiments, the compositions disclosed herein are used for managing chemokine related conditions, typically prevention or treatment of viral infections such as HIV or for managing cancer.