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公开(公告)号：US20100204180A1
公开(公告)日：2010-08-12
申请号：US12704830
申请日：2010-02-12
CPC分类号： C07F5/025 , A61K31/198 , A61K31/454 , A61K31/675 , A61K31/69 , C07C233/83 , C07F5/05
摘要： The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.
摘要翻译： 本发明提供了可用作蛋白酶体抑制剂的新化合物。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US07687662B2
公开(公告)日：2010-03-30
申请号：US12217243
申请日：2008-07-02
IPC分类号： C07F5/02 , C07C229/00 , C07C233/00 , C07C235/00 , C07C239/00 , A61K31/69
CPC分类号： C07F5/025 , A61K31/198 , A61K31/454 , A61K31/675 , A61K31/69 , C07C233/83 , C07F5/05
摘要： The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.
摘要翻译： 本发明提供了可用作蛋白酶体抑制剂的新化合物。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US07838673B2
公开(公告)日：2010-11-23
申请号：US11974758
申请日：2007-10-16
CPC分类号： C07F5/025
摘要： The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.
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公开(公告)号：US20090042836A1
公开(公告)日：2009-02-12
申请号：US12217243
申请日：2008-07-02
CPC分类号： C07F5/025 , A61K31/198 , A61K31/454 , A61K31/675 , A61K31/69 , C07C233/83 , C07F5/05
摘要： The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.
摘要翻译： 本发明提供了可用作蛋白酶体抑制剂的新化合物。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US08530694B2
公开(公告)日：2013-09-10
申请号：US13209511
申请日：2011-08-15
IPC分类号： C07F5/02 , C07C229/00 , C07C233/00 , C07C239/00 , C07C235/00 , A61K31/69
CPC分类号： C07F5/025 , A61K31/198 , A61K31/454 , A61K31/675 , A61K31/69 , C07C233/83 , C07F5/05
摘要： The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.
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公开(公告)号：US20110301124A1
公开(公告)日：2011-12-08
申请号：US13209511
申请日：2011-08-15
CPC分类号： C07F5/025 , A61K31/198 , A61K31/454 , A61K31/675 , A61K31/69 , C07C233/83 , C07F5/05
摘要： The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.
摘要翻译： 本发明提供了可用作蛋白酶体抑制剂的新化合物。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US08003819B2
公开(公告)日：2011-08-23
申请号：US12704830
申请日：2010-02-12
IPC分类号： C07F5/02 , C07C229/00 , C07C233/00 , C07C239/00 , C07C235/00 , A61K31/69
CPC分类号： C07F5/025 , A61K31/198 , A61K31/454 , A61K31/675 , A61K31/69 , C07C233/83 , C07F5/05
摘要： The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.
摘要翻译： 本发明提供了可用作蛋白酶体抑制剂的新化合物。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20090099132A1
公开(公告)日：2009-04-16
申请号：US11974758
申请日：2007-10-16
CPC分类号： C07F5/025
摘要： The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.
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公开(公告)号：US07442830B1
公开(公告)日：2008-10-28
申请号：US11890412
申请日：2007-08-06
IPC分类号： C07F5/02 , C07C229/00 , C07C233/00 , C07C235/00 , C07C239/00 , A61K31/69
CPC分类号： C07F5/025 , A61K31/198 , A61K31/454 , A61K31/675 , A61K31/69 , C07C233/83 , C07F5/05
摘要： The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.
摘要翻译： 本发明提供了可用作蛋白酶体抑制剂的新型化合物。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US09029343B2
公开(公告)日：2015-05-12
申请号：US13991321
申请日：2011-12-05
IPC分类号： C07H19/16 , C07H19/167 , C07D473/34
CPC分类号： C07H19/16 , C07D473/34 , C07H19/167
摘要： Disclosed are compounds, pharmaceutical compositions containing the compounds, and the uses of the compounds and compositions as modulators of histone methyltransferases, and for treating diseases influenced by modulation of histone methyltransferase activity.
摘要翻译： 公开了化合物，含有这些化合物的药物组合物，以及化合物和组合物作为组蛋白甲基转移酶调节剂的用途，以及用于治疗受组蛋白甲基转移酶活性调节影响的疾病。
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