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公开(公告)号：US20210206706A1
公开(公告)日：2021-07-08
申请号：US17059762
申请日：2019-05-30
发明人： Kong Joo Lee , Hee-Yoon Lee , Je Jin Lee , Hongsoo Lee , Ji-wan Seo , Hwang Suk Kim , Bo-kyung Kim , Ji Soo Shin
IPC分类号： C07C43/23 , C07C49/175 , A61K31/337 , A61K31/12 , A61K31/09 , A61P35/00 , A61K9/00 , A23L33/00 , A23L33/10
摘要： The present disclosure provides a novel biphenyl derivative compound, an optical isomer thereof or a pharmaceutically acceptable salt thereof. The biphenyl derivative compound, optical isomer thereof or pharmaceutically acceptable salt thereof according to the present disclosure may induce cancer cell death by damaging mitochondria and inducing ATP depletion in cells which are in a nutrient-starved state such as a glucose-starved state, which is the normal environment of cancer cells. In addition, it is an Nm23-H1/NDPK activity-increasing substance that may suppress cancer metastasis and growth. Thus, it exhibits excellent effects not only on the prevention, alleviation and treatment of cancer, but also on the suppression of cancer metastasis.
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公开(公告)号：US12043594B2
公开(公告)日：2024-07-23
申请号：US17059762
申请日：2019-05-30
发明人： Kong Joo Lee , Hee-Yoon Lee , Je Jin Lee , Hongsoo Lee , Ji-wan Seo , Hwang Suk Kim , Bo-kyung Kim , Ji Soo Shin
IPC分类号： C07C43/23 , A23L33/00 , A23L33/10 , A61K9/00 , A61K31/09 , A61K31/12 , A61K31/337 , A61P35/00 , C07C49/175
CPC分类号： C07C43/23 , A23L33/10 , A23L33/40 , A61K9/0056 , A61K31/09 , A61K31/12 , A61K31/337 , A61P35/00 , C07C49/175 , A23V2002/00
摘要： The present disclosure provides a novel biphenyl derivative compound, an optical isomer thereof or a pharmaceutically acceptable salt thereof. The biphenyl derivative compound, optical isomer thereof or pharmaceutically acceptable salt thereof according to the present disclosure may induce cancer cell death by damaging mitochondria and inducing ATP depletion in cells which are in a nutrient-starved state such as a glucose-starved state, which is the normal environment of cancer cells. In addition, it is an Nm23-H1/NDPK activity-increasing substance that may suppress cancer metastasis and growth. Thus, it exhibits excellent effects not only on the prevention, alleviation and treatment of cancer, but also on the suppression of cancer metastasis.
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公开(公告)号：US20210214324A1
公开(公告)日：2021-07-15
申请号：US17059754
申请日：2019-05-30
发明人： Kong Joo Lee , Hee-Yoon Lee , Je Jin Lee , Hwang Suk Kim , Ji-wan Seo , Hongsoo Lee , Ji Soo Shin , Bo-kyung Kim
IPC分类号： C07D303/18 , C07C35/21 , C07C43/23 , C07C235/56 , A23L33/10 , A61P35/04
摘要： The present disclosure provides a novel biphenyl derivative compound or a pharmaceutically acceptable salt thereof. The biphenyl derivative compound or pharmaceutically acceptable salt thereof according to the present disclosure is a compound that increases Nm23-H1/NDPK activity and can inhibit cancer metastasis and growth. Thus, it exhibits excellent effects not only on the prevention, alleviation and treatment of cancer, but also on the suppression of cancer metastasis.
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公开(公告)号：US11939308B2
公开(公告)日：2024-03-26
申请号：US17059754
申请日：2019-05-30
发明人： Kong Joo Lee , Hee-Yoon Lee , Je Jin Lee , Hwang Suk Kim , Ji-Wan Seo , Hongsoo Lee , Ji Soo Shin , Bo-kyung Kim
IPC分类号： C07D303/18 , A23L33/10 , A61P35/04 , C07C35/21 , C07C43/23 , C07C235/56
CPC分类号： C07D303/18 , A23L33/10 , A61P35/04 , C07C35/21 , C07C43/23 , C07C235/56
摘要： The present disclosure provides a novel biphenyl derivative compound or a pharmaceutically acceptable salt thereof. The biphenyl derivative compound or pharmaceutically acceptable salt thereof according to the present disclosure is a compound that increases Nm23-H1/NDPK activity and can inhibit cancer metastasis and growth. Thus, it exhibits excellent effects not only on the prevention, alleviation and treatment of cancer, but also on the suppression of cancer metastasis.
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