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公开(公告)号:US20210163408A1
公开(公告)日:2021-06-03
申请号:US17059920
申请日:2019-05-29
申请人: ETH ZURICH
发明人: Cody Ross PITTS , Nico SANTSCHI , Antonio TOGNI
IPC分类号: C07C381/00 , C07C391/02 , C07C395/00 , C07C17/013 , C07C25/13 , C01B17/45 , C07D213/803 , C07D209/48 , C07D253/07 , C07D239/30 , C07D213/89 , C07D231/56 , C07D317/16 , C07C67/307 , C07C201/12 , C07C41/22
摘要: A process for preparing a polyfluorinated compound of formula Ar—R1 (I), wherein Ar—R1 (I) is an aromatic ring system wherein R1 is selected from the group consisting of SF4Cl, SF3, SF2CF3, TeF5, TeF4CF3, SeF3, IF2, SeF2CF3, and IF4, X2 is N or CR2, X3 is N or CR3, X4 is N or CR4, X5 is N or CR5, X6 is N or CR6, and the total number of nitrogen atoms in the aromatic ring system is between 0 and 3, wherein R2, R3, R4, R5 and R6 are independently selected from the group consisting of hydrogen, fluoro, chloro, bromo, nitro, trifluoromethyl, 2,2,2-trifluoroethyl, pentafluorosulfanyl, phthalimido, azido, benzyloxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, methoxycarbonyl, ethoxycarbonyl, methylcarbonyl, ethylcarbonyl, acetoxy, t-butyl, phenylcarbonyl, benzylcarbonyl, 3-trifluoromethylphenyl, phenylsulfonyl, methylsulfonyl, chlorophenyl, methyldoxolonyl, methyl, isopropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, fluoromethyl, fluoroethyl and phenyl.
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公开(公告)号:US20190040036A1
公开(公告)日:2019-02-07
申请号:US16055629
申请日:2018-08-06
申请人: ETH Zurich , INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ACADEMY OF SCIENCES OF THE CZECH REPUBLIC, V.V.I
发明人: Vaclav MATOUSEK , Petr BEIER , Antonio TOGNI
IPC分类号: C07D347/00
CPC分类号: C07D347/00 , C07D421/06
摘要: Described herein are hypervalent iodine reagents.
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公开(公告)号:US20170233420A1
公开(公告)日:2017-08-17
申请号:US15501872
申请日:2015-08-03
申请人: ETH Zurich , INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ACADEMY OF SCIENCES OF THE CZECH REPUBLIC, V.V.I
发明人: Vaclav MATOUSEK , Petr BEIER , Antonio TOGNI
IPC分类号: C07F9/6561 , C07D421/06 , C07D347/00
CPC分类号: C07F9/65616 , C07D347/00 , C07D421/06
摘要: A hypervalent iodine of formula (I) or formula (II) wherein R is a nucleophile and a method for their production is described. Such compounds can be used for fluoroethylation of compounds carrying a reactive group. A preferred compound carrying a reactive group is cystein in any environment such as peptide targets.
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