公开(公告)号：US12102608B2

公开(公告)日：2024-10-01

申请号：US17825260

申请日：2022-05-26

申请人： EPITECH GROUP S.P.A.

发明人： Francesco Della Valle ,  Maria Federica Della Valle ,  Gabriele Marcolongo ,  Chiara Gomiero

IPC分类号： A61K31/164 ,  A23L33/115

CPC分类号： A61K31/164 ,  A23L33/115

摘要： A composition of acylethanolamides is obtained from olive oil fatty acids and is used in treating neuroinflammation. The acylethanolamide complex includes (weight percentages):
















oleoylethanolamide (OEA) C18:1
60-65% 



palmitoylethanolamide (PEA) C16:0
5-20%



linoleylethanolamide (LEA) C18:2
5-20%



stearoylethanolamide (SEA) C18:0
 1-2%



palmitoylethanolamide (POEA) C16:1
0.1-0.8% 



myristoylethanolamide (MEA) C14:0
0.02-0.15%  



mixture of glycerides
 4-6%



glycerol
 6-8%.










A method obtains the acylethanolamide complex and formulations contain the acylethanolamide complex.

公开(公告)号：US20220304954A1

公开(公告)日：2022-09-29

申请号：US17213856

申请日：2021-03-26

申请人： Epitech Group S.p.A.

发明人： Francesco Della Valle ,  Maria Federica Della Valle ,  Gabriele Marcolongo ,  Giuliano Claps ,  Chiara Gomiero ,  Vito Safina

IPC分类号： A61K31/16 ,  A23L33/12

摘要： The present invention relates to a method of treating a COVID-19 infection by administering an effective amount of an endogenous compound devoid of significant toxicity. In particular, the present invention relates to a method of treating a patient affected by COVID-19 infection comprising administering an effective amount of a mixture of ultra-micronized palmitoylethanolamide and micronized palmitoylethanolamide to said patient.