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公开(公告)号:US20140073055A1
公开(公告)日:2014-03-13
申请号:US13776526
申请日:2013-02-25
发明人: Cory John Gerdts , Mark William Elliott , Peter Kurt Nollert-von Specht , Lansing Joseph Stewart
IPC分类号: B01D9/00
CPC分类号: B01D9/0072 , B01D9/00 , Y10T428/31855
摘要: A nanovolume microcapillary crystallization system allows nanoliter-volume screening of crystallization conditions in a crystal card that allows crystals to either be removed for traditional cryoprotection or in situ X-ray diffraction studies on protein crystals that grow within. The system integrates formulation of crystallization cocktails with preparation of the crystallization experiments. The system allows the researcher to select either gradient screening in crystallization experiments for efficient exploration of crystallization phase space or a combination of sparse matrix with gradient screening to execute one comprehensive hybrid crystallization trial.
摘要翻译: 纳米级微毛细管结晶系统允许纳米级体积筛选晶体卡中的结晶条件,其允许将晶体除去用于传统的冷冻保护或在其内生长的蛋白质晶体的原位X射线衍射研究。 该系统将结晶鸡尾酒配方与结晶实验的准备相结合。 该系统允许研究者选择结晶实验中的梯度筛选,以有效探索结晶相空间,或者通过梯度筛选稀释基质的组合进行一次综合混合结晶试验。