公开(公告)号：US20230310582A1

公开(公告)日：2023-10-05

申请号：US17919111

申请日：2021-04-14

Applicant: Duke University

Inventor： Rory Henderson ,  Kevin Saunders ,  Barton F. Haynes ,  Priyamvada Acharya

IPC: A61K39/215 ,  C07K14/005 ,  A61P31/14

CPC classification number: A61K39/215 ,  C07K14/005 ,  A61P31/14

Abstract: The invention provides SARS-2 spike protein designs and uses thereof.

公开(公告)号：US12138304B2

公开(公告)日：2024-11-12

申请号：US17281918

申请日：2019-09-05

Applicant: Duke University

Inventor： Rory Henderson ,  S. Munir Alam ,  Barton F. Haynes ,  Kevin J. Wiehe

IPC: A61K39/12 ,  C07K14/16 ,  C12N7/00 ,  C12N15/63

Abstract: The technology is directed to HIV envelopes which comprise sequence modifications wherein these modifications prevent CD4-induced transitions of the HIV envelope. Specifically, the disclosure provides recombinant HIV-1 Env proteins comprising mutations, wherein the envelope is a protomer, and wherein three protomers form a trimer stabilized by the presence of the mutations. Provided also are compositions comprising envelopes of the technology, and methods of use.

公开(公告)号：US20240197854A1

公开(公告)日：2024-06-20

申请号：US18274943

申请日：2022-01-28

Applicant: Duke University

Inventor： Rory Henderson ,  Barton F. Haynes

IPC: A61K39/12 ,  A61K39/00 ,  A61K39/39 ,  A61P31/18 ,  C07K14/005

CPC classification number: A61K39/12 ,  A61K39/39 ,  A61P31/18 ,  C07K14/005 ,  A61K2039/55555 ,  A61K2039/575 ,  C12N2740/16122 ,  C12N2740/16134

Abstract: This invention provides in general, a composition suitable for use in inducing anti-HIV-1 antibodies, such as immunogenic compositions comprising envelope proteins and nucleic acids to induce cross-reactive neutralizing antibodies and increase their breadth of coverage. The invention also provides methods of inducing such broadly neutralizing anti-HIV-1 antibodies using such compositions.