公开(公告)号：US12214056B2

公开(公告)日：2025-02-04

申请号：US16318745

申请日：2017-07-19

Applicant: Duke University

Inventor： Charles A. Gersbach ,  Sarina Madhavan ,  Christopher Nelson

IPC: A61K48/00 ,  A61K31/7105 ,  A61K38/46 ,  A61P21/00 ,  C07K14/47 ,  C12N9/22 ,  C12N15/11 ,  C12N15/113 ,  C12N15/90

Abstract: Disclosed herein are therapeutic applications of CRISPR/Cpf1-based genome editing.

公开(公告)号：US20230032846A1

公开(公告)日：2023-02-02

申请号：US17782112

申请日：2020-12-03

Applicant: Duke University

Inventor： Charles A. Gersbach ,  Christopher Nelson

IPC: A61K48/00 ,  C12N15/90 ,  C12N15/11 ,  C12N9/22 ,  A61K47/69 ,  A61K9/51 ,  A61P21/00

Abstract: The present invention provides DNA targeting systems and methods for delivery of gene editing machinery using lipid nanoparticles or microparticles.

公开(公告)号：US20190151476A1

公开(公告)日：2019-05-23

申请号：US16318745

申请日：2017-07-19

Applicant: Duke University

Inventor： Charles A. Gersbach ,  Sarina Madhavan ,  Christopher Nelson

IPC: A61K48/00 ,  A61P21/00

Abstract: Disclosed herein are therapeutic applications of CRISPR/Cpf1-based genome editing.