-
公开(公告)号：US09375404B2
公开(公告)日：2016-06-28
申请号：US14746635
申请日：2015-06-22
申请人： Duchesnay Inc.
IPC分类号： A61K9/24 , A61K31/4402 , A61K9/00 , A61K31/4415 , A61K31/675
CPC分类号： A61K9/209 , A61K9/0053 , A61K9/006 , A61K31/4402 , A61K31/4415 , A61K31/675 , A61K2300/00
摘要： A dual release oral dosage system/dosage form comprising an immediate release component/composition and a delayed release component/composition is described. Each of the immediate release component/composition and delayed release component/composition comprises one or more of doxylamine, an analog thereof, a derivative thereof, a prodrug thereof, a metabolite thereof and/or a salt thereof, and one or more of pyridoxine, a salt thereof, a metabolite thereof and/or a salt of the metabolite. The dual release oral dosage system/dosage form exhibits an improved pharmacokinetic profile relative to the current Diclectin® formulation and is useful for example for the alleviation of the symptoms of nausea and vomiting, for example in the case of nausea and vomiting in pregnancy (NVP).
-
2.发明授权Plurimodal release formulation of doxylamine and pyridoxine and/or metabolites or salts thereof 有权多莫胺和吡哆醇和/或其代谢物或其盐的多峰释放制剂公开(公告)号：US09526703B2
公开(公告)日：2016-12-27
申请号：US14839859
申请日：2015-08-28
申请人： Duchesnay Inc.
IPC分类号： A61K9/42 , A61K9/24 , A61K31/4415 , A61K9/20 , A61K31/4402 , A61K9/28 , A61K31/00
CPC分类号： A61K9/209 , A61K9/2027 , A61K9/2846 , A61K9/2866 , A61K31/00 , A61K31/4402 , A61K31/4415 , A61K2300/00
摘要： A solid oral dosage form comprising a core comprising a doxylamine component and a pyridoxine component coated with an enteric coating is disclosed. The solid oral dosage form further comprises two active ingredient-containing coatings surrounding the enteric coating, the active ingredient-containing coatings being separated from one another by an intermediate coating, and one of the two active ingredient-containing coatings comprising a doxylamine component and being free of a pyridoxine component, and the other of the two active ingredient-containing coatings comprising a pyridoxine component and being free of doxylamine component. Uses of the solid oral dosage form for the alleviation of the symptoms of nausea and vomiting, for example in the case of nausea and vomiting of pregnancy (NVP), are also disclosed.
摘要翻译： 公开了一种固体口服剂型，其包含包含多西胺组分的核心和涂有肠溶衣的吡哆醇组分。 固体口服剂型还包括围绕肠溶衣的两种含活性成分的包衣，含活性成分的包衣通过中间涂层彼此分离，并且两种含活性成分的包衣中的一种包含多木胺组分， 不含吡哆醇成分，两种含有活性成分的涂层中的另一种含有吡哆醛成分，且不含多西胺成分。 还公开了用于减轻恶心和呕吐症状的固体口服剂型的用途，例如在怀孕恶心和呕吐（NVP）的情况下）。
-
公开(公告)号：US09439920B2
公开(公告)日：2016-09-13
申请号：US14506387
申请日：2014-10-03
申请人： Duchesnay Inc.
IPC分类号： A61K31/7076 , A61K31/4402 , A61K31/4415 , A61K31/525 , A61K31/675 , A61P1/08
CPC分类号： A61K31/7076 , A61K31/4402 , A61K31/4415 , A61K31/525 , A61K31/675
摘要： A pharmaceutical dosage system comprising (a) an effective amount of one or more of Doxylamine, an analog thereof, a derivative thereof, a prodrug thereof, a metabolite thereof and/or a salt thereof; (b) an effective amount of one or more of (i) Pyridoxine, (ii) an analog thereof, (iii) a derivative thereof, (iv) a prodrug thereof, (v) a metabolite thereof and (vi) a salt of any of (i)-(v); and (c) an effective amount of one or more compounds of formula (I) wherein R is H, PO3- or The system exhibits an improved pharmacokinetic profile relative to the current Diclectin®/Diclegis® formulation and is useful for example for the alleviation of the symptoms of nausea and vomiting, for example in the case of nausea and vomiting of pregnancy (NVP).
-
公开(公告)号：US10028941B2
公开(公告)日：2018-07-24
申请号：US14907248
申请日：2014-03-13
申请人： DUCHESNAY INC.
IPC分类号： A61K31/4402 , A61K31/4415 , A61K31/525 , A61K31/7076 , A61K9/00 , A61K31/519 , A61K31/675 , A61K31/661 , A61K31/7084
CPC分类号： A61K31/4402 , A61K9/0053 , A61K31/4415 , A61K31/519 , A61K31/525 , A61K31/661 , A61K31/675 , A61K31/7076 , A61K31/7084 , A61K2300/00
摘要： A pharmaceutical dosage system comprising (a) an effective amount of one or more of Doxylamine, an analog thereof, a derivative thereof, a prodrug thereof, a metabolite thereof and/or a salt thereof; (b) an effective amount of one or more of (i) Pyridoxine, (ii) an analog thereof, (iii) a derivative thereof, (iv) a prodrug thereof, (v) a metabolite thereof and (vi) a salt of any of (i)-(v); and (c) an effective amount of one or more compounds of formula (I) wherein R is H, PO3 or. The system exhibits an improved pharmacokinetic profile relative to the current Diclectin®/Diclegis® formulation and is useful for example for the alleviation of the symptoms of nausea and vomiting, for example in the case of nausea and vomiting of pregnancy (NVP).
-
公开(公告)号：US09937132B2
公开(公告)日：2018-04-10
申请号：US15163621
申请日：2016-05-24
申请人： Duchesnay Inc.
IPC分类号： A61K9/24 , A61K31/4402 , A61K9/00 , A61K31/4415 , A61K31/675
CPC分类号： A61K9/209 , A61K9/0053 , A61K9/006 , A61K31/4402 , A61K31/4415 , A61K31/675 , A61K2300/00
摘要： A dual release oral dosage system/dosage form comprising an immediate release component/composition and a delayed release component/composition is described. Each of the immediate release component/composition and delayed release component/composition comprises one or more of doxylamine, an analog thereof, a derivative thereof, a prodrug thereof, a metabolite thereof and/or a salt thereof, and one or more of pyridoxine, a salt thereof, a metabolite thereof and/or a salt of the metabolite. The dual release oral dosage system/dosage form exhibits an improved pharmacokinetic profile relative to the current Diclectin® formulation and is useful for example for the alleviation of the symptoms of nausea and vomiting, for example in the case of nausea and vomiting in pregnancy (NVP).
-
公开(公告)号：US09452181B2
公开(公告)日：2016-09-27
申请号：US14228214
申请日：2014-03-27
申请人： Duchesnay Inc.
IPC分类号： A61K31/7076 , A61K31/4402 , A61K31/4415 , A61K31/525 , A61K31/675
CPC分类号： A61K31/7076 , A61K31/4402 , A61K31/4415 , A61K31/525 , A61K31/675
摘要： A pharmaceutical dosage system comprising (a) an effective amount of one or more of Doxylamine, an analog thereof, a derivative thereof, a prodrug thereof, a metabolite thereof and/or a salt thereof; (b) an effective amount of one or more of (i) Pyridoxine, (ii) an analog thereof, (iii) a derivative thereof, (iv) a prodrug thereof, (v) a metabolite thereof and (vi) a salt of any of (i)-(v); and (c) an effective amount of one or more compounds of formula (I) wherein R is H, PO3− or The system exhibits an improved pharmacokinetic profile relative to the current Diclectin®/Diclegis® formulation and is useful for example for the alleviation of the symptoms of nausea and vomiting, for example in the case of nausea and vomiting of pregnancy (NVP).
-
公开(公告)号：US09089489B2
公开(公告)日：2015-07-28
申请号：US14228228
申请日：2014-03-27
申请人： Duchesnay Inc.
IPC分类号： A61K9/24 , A61K31/4402 , A61K9/00 , A61K31/4415 , A61K31/675
CPC分类号： A61K9/209 , A61K9/0053 , A61K9/006 , A61K31/4402 , A61K31/4415 , A61K31/675 , A61K2300/00
摘要： A dual release oral dosage system/dosage form comprising an immediate release component/composition and a delayed release component/composition is described. Each of the immediate release component/composition and delayed release component/composition comprises one or more of doxylamine, an analog thereof, a derivative thereof, a prodrug thereof, a metabolite thereof and/or a salt thereof, and one or more of pyridoxine, a salt thereof, a metabolite thereof and/or a salt of the metabolite. The dual release oral dosage system/dosage form exhibits an improved pharmacokinetic profile relative to the current Diclectin® formulation and is useful for example for the alleviation of the symptoms of nausea and vomiting, for example in the case of nausea and vomiting in pregnancy (NVP).
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.016 秒)
