公开(公告)号：US20120150257A1

公开(公告)日：2012-06-14

申请号：US13374047

申请日：2011-12-07

申请人： Dorian Aur ,  Izumi Toyoda ,  Mark R. Bower ,  Paul Buckmaster

发明人： Dorian Aur ,  Izumi Toyoda ,  Mark R. Bower ,  Paul Buckmaster

IPC分类号： A61N1/36

CPC分类号： A61N1/36171 ,  A61N1/0529 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36096

摘要： A prediction and stimulation system or method is provided for neurological disorders characterized by a local dysfunction in neuronal activity regulation. An array of electrodes detects neuronal electrical activity of selected brain region. A detection module detects in each electrode changes in electric field and neuronal activity. A prediction module predicts for each electrode abnormal regimes determined by neurological disorder. A neuromodulation module interfaced with the electrodes selects one or more electrodes in the array where a predefined threshold has been exceeded and stimulates the brain region through each of these selected electrodes using an intermittent therapeutic stimulation pattern with a frequency between 150 and 200 Hz. The provided therapy allows for seizure prediction and detection with high accuracy, potential low risk and increased battery life. The flexibility of the method and system allows it to be used in different neurological disorders by tuning the parameters using a calibration procedure.

摘要翻译： 提供了一种预测和刺激系统或方法，用于神经功能障碍，其特征在于神经元活动调节中的局部功能障碍。 电极阵列检测所选脑区域的神经元电活动。 检测模块在每个电极中检测电场和神经元活动的变化。 预测模块预测由神经障碍确定的每个电极异常方案。 与电极连接的神经调节模块选择已经超过预定义阈值的阵列中的一个或多个电极，并且使用频率在150和200Hz之间的间歇治疗刺激模式来刺激通过这些所选择的电极中的每一个的脑区域。 所提供的治疗允许以高精度，潜在的低风险和延长的电池寿命的发作预测和检测。 方法和系统的灵活性允许其通过使用校准程序调整参数而被用于不同的神经障碍。

公开(公告)号：US08600513B2

公开(公告)日：2013-12-03

申请号：US13374047

申请日：2011-12-07

申请人： Dorian Aur ,  Izumi Toyoda ,  Mark R Bower ,  Paul Buckmaster

发明人： Dorian Aur ,  Izumi Toyoda ,  Mark R Bower ,  Paul Buckmaster

IPC分类号： A61N1/36

CPC分类号： A61N1/36171 ,  A61N1/0529 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36096

摘要： A prediction and stimulation system or method is provided for neurological disorders characterized by a local dysfunction in neuronal activity regulation. An array of electrodes detects neuronal electrical activity of selected brain region. A detection module detects in each electrode changes in electric field and neuronal activity. A prediction module predicts for each electrode abnormal regimes determined by neurological disorder. A neuromodulation module interfaced with the electrodes selects one or more electrodes in the array where a predefined threshold has been exceeded and stimulates the brain region through each of these selected electrodes using an intermittent therapeutic stimulation pattern with a frequency between 150 and 200 Hz. The provided therapy allows for seizure prediction and detection with high accuracy, potential low risk and increased battery life. The flexibility of the method and system allows it to be used in different neurological disorders by tuning the parameters using a calibration procedure.

摘要翻译： 提供了一种预测和刺激系统或方法，用于神经功能障碍，其特征在于神经元活动调节中的局部功能障碍。 电极阵列检测所选脑区域的神经元电活动。 检测模块在每个电极中检测电场和神经元活动的变化。 预测模块预测由神经障碍确定的每个电极异常方案。 与电极连接的神经调节模块选择已经超过预定义阈值的阵列中的一个或多个电极，并且使用频率在150和200Hz之间的间歇治疗刺激模式来刺激通过这些所选择的电极中的每一个的脑区域。 所提供的治疗允许以高精度，潜在的低风险和延长的电池寿命的发作预测和检测。 方法和系统的灵活性允许其通过使用校准程序调整参数而被用于不同的神经障碍。

公开(公告)号：US11298542B2

公开(公告)日：2022-04-12

申请号：US16571286

申请日：2019-09-16

申请人： Dorian Aur

发明人： Dorian Aur

IPC分类号： A61N1/36 ,  A61B5/00 ,  G16H70/40 ,  G16H50/30 ,  G16H50/20 ,  A61B6/00 ,  A61B5/30

摘要： A brain mapping system and methods that allow to predict and monitor the risk of suicide and provide personalized therapy. The brain mapping system and methods detect if brain dysfunctions (injuries) are located in suicidal hubs that trigger increased suicidal ideation and high risk of suicide. The brain mapping technology is suited for different technologies and allows to monitor the effects of therapy, provide precise therapy to decrease the risk of suicide.

公开(公告)号：US20210077814A1

公开(公告)日：2021-03-18

申请号：US16571286

申请日：2019-09-16

申请人： Dorian Aur

发明人： Dorian Aur

IPC分类号： A61N1/36 ,  A61B5/04 ,  A61B5/00 ,  A61B6/00 ,  G16H50/30 ,  G16H50/20 ,  G16H70/40

摘要： A brain mapping system and methods that allow to predict and monitor the risk of suicide and provide personalized therapy. The brain mapping system and methods detect if brain dysfunctions (injuries) are located in suicidal hubs that trigger increased suicidal ideation and high risk of suicide. The brain mapping technology is suited for different technologies and allows to monitor the effects of therapy, provide precise therapy to decrease the risk of suicide.

公开(公告)号：US20210045645A1

公开(公告)日：2021-02-18

申请号：US16538999

申请日：2019-08-13

申请人： Dorian Aur

发明人： Dorian Aur

IPC分类号： A61B5/04 ,  A61B5/0476 ,  A61B5/00 ,  G16H20/10 ,  G16H50/50

摘要： A brain mapping system and methods for providing personalized therapy for a broad range of brain dysfunctions by determining the location and the extent of the brain regions that have to be therapeutically targeted in each subject. The present invention includes means to record specific characteristics of brain activity, detect and display brain regions that present signatures of disease or dysfunctions by using a computing system. The therapy is tuned to target detected brain regions to restore specific connectivity characteristics using invasive, non-invasive stimulation, neurofeedback or drug administration. While connectivity characteristics are estimated based on resting state recordings the therapy will be performed in successive steps to alter network fragmentation in dysfunctional brain regions. The improved treatment is tailored to individual patients that will learn how to reshape specific connectivity characteristics to target the determined location and the extent of brain regions and maximize the therapeutic potential. The brain mapping technology is suited for different technologies and not limited to electroencephalography (EEG) or magneto electroencephalography (MEG).