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1.发明授权Composition intended for use for retarding hair loss and for inducing and stimulating its growth, containing 2-aminopyrimidine 3-oxide derivatives, and new compounds derived from 2-aminopyrimidine 3-oxide 失效用于延缓脱发和诱导和刺激其生长的含有2-氨基嘧啶3-氧化物衍生物的组合物和衍生自2-氨基嘧啶3-氧化物的新化合物
公开(公告)号：US5610302A
公开(公告)日：1997-03-11
申请号：US461848
申请日：1995-06-05
IPC分类号： C07D239/47 , A61K8/00 , A61K8/33 , A61K8/34 , A61K8/36 , A61K8/365 , A61K8/37 , A61K8/39 , A61K8/42 , A61K8/49 , A61K31/41 , A61K31/505 , A61K31/517 , A61K31/519 , A61K31/535 , A61P17/00 , A61P17/14 , A61Q5/00 , A61Q5/02 , A61Q7/00 , C07D239/42 , C07D239/46 , C07D239/48 , C07D239/95 , C07D498/04 , C07D239/22
CPC分类号： C07D239/42 , A61K8/4953 , A61Q7/00 , C07D239/47 , C07D239/48 , C07D239/95
摘要： Composition for retarding hair loss and for inducing and stimulating its growth, containing at least one compound of formula: ##STR1## where R denotes H, alkyl or a ring of formula: ##STR2## X denotes ##STR3## --OR.sub.3, --SR.sub.4 with: the remaining variables defined below in the body of the specification.
摘要翻译： 含有至少一种下式的化合物：其中R表示H，烷基或下式的环的化合物：其中R表示下式的化合物：其中R表示H， -SR4：其余变量定义在下面的规范体内。
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2.发明授权
公开(公告)号：US5760043A
公开(公告)日：1998-06-02
申请号：US768533
申请日：1996-12-18
IPC分类号： C07D239/47 , A61K8/00 , A61K8/33 , A61K8/34 , A61K8/36 , A61K8/365 , A61K8/37 , A61K8/39 , A61K8/42 , A61K8/49 , A61K31/41 , A61K31/505 , A61K31/517 , A61K31/519 , A61K31/535 , A61P17/00 , A61P17/14 , A61Q5/00 , A61Q5/02 , A61Q7/00 , C07D239/42 , C07D239/46 , C07D239/48 , C07D239/95 , C07D498/04
CPC分类号： C07D239/42 , A61K8/4953 , A61Q7/00 , C07D239/47 , C07D239/48 , C07D239/95
摘要： Compositions intended for use for retarding hair loss and for inducing and stimulating its growth, containing 2-aminopyrimidine 3-oxide derivatives, and new compounds derived from 2-aminopyrimidine 3-oxide. Composition for retarding hair loss and for inducing and stimulating its growth, containing at least one compound of formula: ##STR1## where R denotes H, alkyl or a ring of formula: ##STR2## X denotes ##STR3## with: R.sub.1 and R.sub.3 denote H, alkyl, optionally substituted, alkenyl, cycloalkyl, aralkyl or aryl of formula: ##STR4## where R.sub.9 and R.sub.10 denote H, alkyl, hydroxyl, alkoxy or halogen; or form a heterocycle with the nitrogen; R.sub.3 denotes alkyl, alkenyl, cycloalkyl, aralkyl, optionally substituted phenyl; R.sub.4 is identical to R.sub.3 ; Y denotes O or --OSO.sub.3.sup..crclbar. ; R' denotes H or ##STR5## R.sub.5 and R.sub.6 are alkyl; R.sub.7 and R.sub.8 denote H or alkyl; or its physiologically acceptable addition salts with acids.
摘要翻译： 用于延缓脱发并诱导和刺激其生长的组合物，其含有2-氨基嘧啶3-氧化物衍生物和衍生自2-氨基嘧啶3-氧化物的新化合物。 含有至少一种下式的化合物：其中R表示H，烷基或下式的环：X表示
与：R1 R 3表示H，烷基，任选取代的，烯基，环烷基，芳烷基或芳基，其中R 9和R 10表示H，烷基，羟基，烷氧基或卤素; 或与氮形成杂环; R3表示烷基，烯基，环烷基，芳烷基，任选取代的苯基; R4与R3相同; Y表示O或-OSO 3（ - ）; R'表示H或R 5，R 6表示烷基; R7和R8表示H或烷基; 或其生理上可接受的与酸的加成盐。 -
3.发明授权Composition intended to be used for retarding hair loss and for inducing and stimulating hair growth, containing 2-alkyl-4-aminopyrimidine (or 2,4-dialkylpyrimidine) 3-oxide derivatives and new compounds derived from 2-alkyl-4-aminopyrimidine 3-oxide 失效用于延缓脱发并诱导和刺激毛发生长的组合物，其含有2-烷基-4-氨基嘧啶（或2,4-二烷基嘧啶）3-氧化物衍生物和衍生自2-烷基-4-氨基嘧啶3的新化合物 氧化物
公开(公告)号：US5438058A
公开(公告)日：1995-08-01
申请号：US221443
申请日：1994-04-01
IPC分类号： A61K8/00 , A61K8/33 , A61K8/34 , A61K8/36 , A61K8/365 , A61K8/37 , A61K8/39 , A61K8/41 , A61K8/42 , A61K8/49 , A61K31/505 , A61K31/506 , A61K31/535 , A61P17/14 , A61Q5/00 , A61Q7/00 , C07D239/34 , C07D239/42 , C07D239/46 , C07D239/47 , C07D239/48 , C07D498/04 , C07D239/24
CPC分类号： C07D239/48 , A61K8/4953 , A61Q7/00 , C07D239/34 , C07D239/42 , C07D239/47
摘要： Pharmaceutical or cosmetic composition intended to be used, by topical application, for retarding hair loss and for inducing or stimulating hair growth, containing at least one compound of formula: ##STR1## where: R.sub.1 denotes H or C.sub.1 -C.sub.8 alkyl;R.sub.2 denotes C.sub.1 -C.sub.8 alkyl or NHR.sub.3, where R.sub.3 denotes H or --COOR.sub.4, where R.sub.4 denotes C.sub.1 -C.sub.4 alkyl;X denotes ##STR2## --OR.sub.9 or --SR.sub.10 ; R.sub.5 and R.sub.6 denote H, optionally substituted C.sub.1 -C.sub.12 alkyl, or C.sub.2 -C.sub.12 alkenyl, C.sub.3 -C.sub.10 cycloalkyl, aralkyl or aryl, or form, with N, a saturated or unsaturated heterocycle;R.sub.9 denotes optionally substituted C.sub.1 -C.sub.12 alkyl, or C.sub.2 -C.sub.12 alkenyl, C.sub.3 -C.sub.10 cycloalkyl, C.sub.7 -C.sub.12 aralkyl or phenyl, which may optionally be substituted;R.sub.10 is identical to R.sub.9 ; andY denotes O or OSO.sub.3.sup..crclbar. ;as well as its cosmetically or pharmaceutically acceptable acid addition salts.
摘要翻译： 旨在通过局部施用用于延缓脱发和诱导或刺激毛发生长的药物或化妆品组合物，其含有至少一种下式化合物： R2表示C1-C8烷基或NHR3，其中R3表示H或-COOR4，其中R4表示C1-C4烷基; X表示图像-OR9或-SR10; R5和R6表示H，任选取代的C 1 -C 12烷基或C 2 -C 12烯基，C 3 -C 10环烷基，芳烷基或芳基，或与N，饱和或不饱和杂环形成; R 9表示可任意取代的C 1 -C 12烷基或C 2 -C 12烯基，C 3 -C 10环烷基，C 7 -C 12芳烷基或苯基; R10与R9相同; Y表示O或OSO 3（ - ）; 以及其化妆品或药学上可接受的酸加成盐。
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