公开(公告)号：US20220365070A1

公开(公告)日：2022-11-17

申请号：US17761545

申请日：2020-09-17

Applicant: Dewpoint Therapeutics, Inc.

Inventor： Avinash PATEL ,  Mark Andrew MURCKO ,  Stephen Paul HALE ,  Bruce Aaron BEUTEL ,  Bozena KESIC ,  Juwina WIJAYA ,  John C. MANTEIGA ,  Peter Jeffrey DANDLIKER ,  Ann D. KWONG

IPC: G01N33/50

Abstract: The present disclosure, in some aspects, is directed to methods for screening and identifying compounds that modulate one or more characteristics associated with a condensate comprising a RBM20 polypeptide and/or the RBM20 polypeptide. In other aspects, the disclosure is directed to systems and composition components thereof, such as cellular models useful for the methods described herein.

公开(公告)号：US20240145034A1

公开(公告)日：2024-05-02

申请号：US18279760

申请日：2022-03-01

Applicant: Dewpoint Therapeutics, Inc.

Inventor： William W. CHEN ,  John C. MANTEIGA ,  Violeta YU ,  Ann D. KWONG ,  Peter Jeffrey DANDLIKER ,  Bruce Aaron BEUTEL ,  Chi ZHANG ,  Lingyao ZENG ,  Andreas STEFFEN ,  Daniel Franz FREITAG

IPC: G16B20/20 ,  C12N15/10 ,  G16B40/20 ,  G16H70/40

CPC classification number: G16B20/20 ,  C12N15/1079 ,  C12N15/1089 ,  G16B40/20 ,  G16H70/40

Abstract: The present application provides, in some aspects, methods of identifying a condensate of interest associated with a el disease. Also provided are methods of identifying a marker for identifying a condensate of interest associated with a disease. In other aspects, provided herein are methods of identifying a therapeutic agent useful for treating a disease via the identified condensate of interest.