公开(公告)号：US20220152149A1

公开(公告)日：2022-05-19

申请号：US17429532

申请日：2020-02-06

申请人： Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts

发明人： Peter KRAMMER ,  Heiko WEYD ,  Kevin BODE

IPC分类号： A61K38/17 ,  A61K47/54 ,  A61K9/16 ,  A61P37/06

摘要： The present invention relates to an annexin-coated particle, comprising a negatively charged phospholipid and an annexin non-covalently coupled thereto. The present invention further relates to a composition comprising an annexin-coated particle. Furthermore, the present invention relates to a product for use in a method of preventing or treating a disease selected from a chronic inflammatory disease, an autoimmune disease, an allergy, and a cancer, said product comprising an annexin-coated particle, and/or a composition. The present invention further relates to a method of preparing an annexin-coated particle.

公开(公告)号：US20210230238A1

公开(公告)日：2021-07-29

申请号：US17154477

申请日：2021-01-21

申请人： Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts

发明人： Fatmire BUJUPI ,  Peter KRAMMER ,  Heiko WEYD

IPC分类号： C07K14/47 ,  A61K39/39 ,  A61K47/64 ,  A61P35/00 ,  C07K14/74

摘要： The present disclosure provides immunogenic compositions, such as vaccines, including DNA vaccines, and uses thereof, e.g., which include an annexin core domain to mediate efficient antigen delivery and antigen presentation in order to induce an antigen-specific immune response and/or to treat or prevent infectious diseases and/or cancer.