公开(公告)号：US11597692B2

公开(公告)日：2023-03-07

申请号：US17174566

申请日：2021-02-12

申请人： Dermavant Sciences GmbH

发明人： Ian Paul Andrews ,  Nicholas Calandra ,  Tyler Andrew Davis ,  Ravinder Reddy Sudini

IPC分类号： C07C39/08 ,  C07C37/02 ,  C07C45/54 ,  C07C45/72 ,  C07C37/00 ,  C07C50/24 ,  C07C51/38 ,  C07C69/716 ,  C07C67/03 ,  C07C67/293 ,  C07C59/353 ,  C07C45/63 ,  C07C51/09 ,  C07C67/343 ,  C07C37/07 ,  A61K31/05

摘要： The present invention provides processes for the preparation of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and novel intermediates used therein. In some embodiments the 3, 5-Dihydroxy-4-isopropyl-trans-stilbene is prepared from (E)-2-chloro-2-isopropyl-5-styrylcyclohexane-1,3-dione. Also disclosed are crystal forms of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and pharmaceutical compositions comprising same.

公开(公告)号：US10647649B2

公开(公告)日：2020-05-12

申请号：US16189268

申请日：2018-11-13

申请人： Dermavant Sciences GmbH

发明人： Ian Paul Andrews ,  Nicholas Calandra ,  Tyler Andrew Davis ,  Ravinder Reddy Sudini

IPC分类号： C07C39/08 ,  C07C37/00 ,  C07C51/00 ,  C07C67/00 ,  A61K31/00 ,  C07C50/24 ,  C07C51/38 ,  C07C69/716 ,  C07C67/03 ,  C07C67/293 ,  C07C59/353 ,  C07C45/63 ,  C07C51/09 ,  C07C67/343 ,  C07C45/72 ,  C07C45/54 ,  C07C37/07 ,  A61K31/05

摘要： The present invention provides processes for the preparation of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and novel intermediates used therein. In some embodiments the 3, 5-Dihydroxy-4-isopropyl-trans-stilbene is prepared from (E)-2-chloro-2-isopropyl-5-styrylcyclohexane-1,3-dione. Also disclosed are crystal forms of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and pharmaceutical compositions comprising same.

公开(公告)号：US10961175B2

公开(公告)日：2021-03-30

申请号：US16849346

申请日：2020-04-15

申请人： Dermavant Sciences GmbH

发明人： Ian Paul Andrews ,  Nicholas Calandra ,  Tyler Andrew Davis ,  Ravinder Reddy Sudini

IPC分类号： C07C39/08 ,  C07C37/00 ,  C07C50/00 ,  C07C51/38 ,  C07C67/00 ,  C07C67/03 ,  C07C69/716 ,  C07C59/353 ,  C07C45/63 ,  C07C51/09 ,  C07C67/343 ,  C07C45/72 ,  C07C45/54 ,  C07C37/07 ,  C07C50/24 ,  C07C67/293 ,  A61K31/05

摘要： The present invention provides processes for the preparation of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and novel intermediates used therein. In some embodiments the 3, 5-Dihydroxy-4-isopropyl-trans-stilbene is prepared from (E)-2-chloro-2-isopropyl-5-styrylcyclohexane-1,3-dione. Also disclosed are crystal forms of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and pharmaceutical compositions comprising same.