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公开(公告)号：US20190249155A1
公开(公告)日：2019-08-15
申请号：US16355339
申请日：2019-03-15
CPC分类号： C12N9/16 , A61K38/00 , A61K47/68 , A61P3/00 , C07K14/00 , C07K16/28 , C07K19/00 , C07K2319/30 , C12N15/62 , C12Y301/06013
摘要： Provided herein are fusion proteins that comprise an enzyme replacement therapy enzyme and an Fc region, as well as methods of using such proteins to treat a lysosomal storage disorder. Methods for transporting agents across the blood-brain barrier are also provided herein.
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公开(公告)号：US20220177576A1
公开(公告)日：2022-06-09
申请号：US17478587
申请日：2021-09-17
发明人： Mark S. Dennis , Zhenyu Gu , Mihalis Kariolis , Cathal Mahon , Kathryn M. Monroe , Joshua I. Park , Rachel Prorok , Adam P. Silverman , Bettina Van Lengerich
IPC分类号： C07K16/28
摘要： In one aspect, antibodies that specifically bind to a human triggering receptor expressed on myeloid cells 2 (TREM2) protein are provided. In some embodiments, the antibody decreases levels of soluble TREM2 (sTREM2). In some embodiments, the antibody enhances TREM2 activity.
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公开(公告)号：US20210198640A1
公开(公告)日：2021-07-01
申请号：US17102138
申请日：2020-11-23
发明人： Giuseppe Astarita , Mark S. Dennis , Jennifer A. Getz , Anastasia Henry , Mihalis Kariolis , Cathal Mahon , Adam P. Silverman , Ankita Srivastava , Julie Ullman , Junhua Wang , Joy Yu Zuchero
摘要： Provided herein are fusion proteins that comprise an enzyme replacement therapy enzyme and an Fc region, as well as methods of using such proteins to treat a lysosomal storage disorder. Methods for transporting agents across the blood-brain barrier are also provided herein.
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