公开(公告)号：US11771624B2

公开(公告)日：2023-10-03

申请号：US17581665

申请日：2022-01-21

Applicant: DURECT CORPORATION

Inventor： Andrew R. Miksztal ,  Judy Joice ,  Susan Autio ,  Mark P. Davis

IPC: A61J1/20 ,  A61K31/445 ,  A61K47/10 ,  A61K47/26

CPC classification number: A61J1/2089 ,  A61K31/445 ,  A61K47/10 ,  A61K47/26

Abstract: The present disclosure relates to sustained release drug delivery systems. In some cases, a composition comprises an active pharmaceutical agent; at least one of sucrose acetate isobutyrate and a polyorthoester; an organic solvent; and 2,6-dimethylaniline, wherein the 2,6-dimethylaniline is present at a level less than 500 ppm. In some cases, a composition comprises N-oxide of active pharmaceutical agent at a level less than 1 wt %, based on weight of the composition. In some case, a composition comprises metal present at a level less than 5 ppm. Dosage forms and methods are also provided.

公开(公告)号：US20220257619A1

公开(公告)日：2022-08-18

申请号：US17627000

申请日：2020-07-17

Applicant: Gilead Sciences, Inc. ,  Durect Corporation

Inventor： Susan Autio ,  Keith Edward Branham ,  James A. Filice ,  John W. Gibson ,  John J. Leonard ,  James Matriano ,  Whitney Moro ,  Michael Sekar ,  Chelsea Alexandra Snyder ,  Robert G. Strickley ,  Raju Subramanian ,  Felix Theeuwes ,  Monica Tijerina ,  Jeremy C. Wright ,  Su Il Yum ,  Faye Xu

IPC: A61K31/675 ,  A61K47/26 ,  A61K47/34 ,  A61K47/22 ,  A61P31/18

Abstract: The present disclosure provides long-acting formulations of tenofovir alafenamide, methods of making the same and methods of using the same.