公开(公告)号：US20240294576A1

公开(公告)日：2024-09-05

申请号：US17919997

申请日：2021-05-05

申请人： DUKE UNIVERSITY

发明人： Aravind Asokan ,  Zachary Elmore ,  Lawrence Patrick Havlik ,  Daniel K. Oh

IPC分类号： C07K14/005 ,  A61K38/46 ,  A61K47/64 ,  C12N15/86

CPC分类号： C07K14/005 ,  A61K38/465 ,  A61K47/64 ,  C12N15/86 ,  C12N2750/14122 ,  C12N2750/14143 ,  C12N2750/14152

摘要： Disclosed herein are compositions and methods for enhancing secretion of extracellular vesicles and/or AAV particles from cells. Disclosed herein are compositions and methods for altering and/or modifying the formation and/or secretion of extracellular vesicles and/or AAV particles from cells. Disclosed herein are compositions and methods for loading extracellular vesicles and or AAV particles with a cargo. Disclosed herein are isolated nucleic acid molecules encoding a polypeptide for promoting the formation of extracellular vesicles and AAV particles in cell or a polypeptide associated with extracellular vesicles and/or AAV particles secreted from a cell.

公开(公告)号：US12037598B2

公开(公告)日：2024-07-16

申请号：US18474533

申请日：2023-09-26

申请人： Duke University

发明人： Aravind Asokan ,  Trevor Gonzalez ,  Lawrence Patrick Havlik

IPC分类号： C12N15/86 ,  C07K14/005

CPC分类号： C12N15/86 ,  C07K14/005 ,  C12N2750/14122 ,  C12N2750/14143

摘要： The present disclosure provides adeno-associated virus (AAV) vectors, comprising coevolved capsid variant proteins, pharmaceutical compositions, methods of making, and methods for delivering such to a subject.

公开(公告)号：US20240067988A1

公开(公告)日：2024-02-29

申请号：US18474506

申请日：2023-09-26

申请人： Duke University

发明人： Aravind Asokan ,  Trevor Gonzalez ,  Lawrence Patrick Havlik

IPC分类号： C12N15/86 ,  C07K14/005

CPC分类号： C12N15/86 ,  C07K14/005 ,  C12N2750/14122 ,  C12N2750/14143

摘要： The present disclosure provides adeno-associated virus (AAV) vectors, comprising coevolved capsid variant proteins, pharmaceutical compositions, methods of making, and methods for delivering such to a subject.

公开(公告)号：US20230151389A1

公开(公告)日：2023-05-18

申请号：US17922962

申请日：2021-05-05

申请人： Duke University

发明人： Aravind Asokan ,  Trevor Gonzalez ,  Lawrence Patrick Havlik

IPC分类号： C12N15/86 ,  C07K14/005

CPC分类号： C12N15/86 ,  C07K14/005 ,  C12N2750/14122 ,  C12N2750/14143

摘要： The present disclosure provides adeno-associated virus (AAV) vectors, comprising coevolved capsid variant proteins, pharmaceutical compositions, methods of making, and methods for delivering such to a subject.