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    5-benzylaminomethyl-6-aminopyrazolo [3, 4 -B] pyridine derivatives as cholesteryl ester-transfer protein (CETP) inhibitors useful for the treatment of atherosclerosis
    5.
    发明授权
    5-benzylaminomethyl-6-aminopyrazolo [3, 4 -B] pyridine derivatives as cholesteryl ester-transfer protein (CETP) inhibitors useful for the treatment of atherosclerosis 有权
    5-苄基氨基甲基-6-氨基吡唑并[3,4-b]吡啶衍生物作为用于治疗动脉粥样硬化的胆固醇酯转移蛋白（CETP）抑制剂

    公开(公告)号：US09000007B2

    公开(公告)日：2015-04-07

    申请号：US14347519

    申请日：2012-09-27

    申请人： Dr. Reddy's Laboratories, Ltd.

    发明人： Anima Boruah ,  Shanavas Alikunju

    IPC分类号： C07D401/14 ,  A61K31/437 ,  C07D471/04

    CPC分类号： C07D471/04

    摘要： The present application relates to a series of substituted pyra-zolopyridin-6-amines having the general formula (I), including their stereoisomers and/or their pharmaceutically acceptable salts. Wherein R, R1, R2, Ra, Raa, Rb and n are as defined herein. The present invention further relates to pharmaceutical compositions comprising compounds of formula (I). The compounds of this application are useful as CETP inhibitors for increasing HDL cholesterol and decreasing LDL cholesterol in a patient.

    摘要翻译： 本申请涉及一系列具有通式（I）的取代的吡唑并吡啶-6-胺，包括其立体异构体和/或其药学上可接受的盐。 其中R，R1，R2，Ra，Raa，Rb和n如本文所定义。 本发明还涉及包含式（I）化合物的药物组合物。 本申请的化合物可用作增加HDL胆固醇和降低患者体内LDL胆固醇的CETP抑制剂。

    5 - BENZYLAMINOMETHYL - 6 - AMINOPYRAZOLO [3, 4 -B] PYRIDINE DERIVATIVES AS CHOLESTERYL ESTER-TRANSFER PROTEIN (CETP) INHIBITORS USEFUL FOR THE TREATMENT OF ATHEROSCLEROSIS
    6.
    发明申请
    5 - BENZYLAMINOMETHYL - 6 - AMINOPYRAZOLO [3, 4 -B] PYRIDINE DERIVATIVES AS CHOLESTERYL ESTER-TRANSFER PROTEIN (CETP) INHIBITORS USEFUL FOR THE TREATMENT OF ATHEROSCLEROSIS 有权
    5-苯甲酰氨基 - 6-氨基吡唑并[3,4-B]吡啶衍生物作为用于治疗角膜结构的有效的转运蛋白（CETP）抑制剂

    公开(公告)号：US20140288072A1

    公开(公告)日：2014-09-25

    申请号：US14347519

    申请日：2012-09-27

    申请人： DR. REDDY'S LABORATORIES, LTD.

    发明人： Anima Boruah ,  Shanavas Alikunju

    IPC分类号： C07D471/04

    CPC分类号： C07D471/04

    摘要： The present application relates to a series of substituted pyra-zolopyridin-6-amines having the general formula (I), including their stereoisomers and/or their pharmaceutically acceptable salts. Wherein R, R1, R2, Ra, Raa, Rb and n are as defined herein. The present invention further relates to pharmaceutical compositions comprising compounds of formula (I). The compounds of this application are useful as CETP inhibitors for increasing HDL cholesterol and decreasing LDL cholesterol in a patient.

    摘要翻译： 本申请涉及一系列具有通式（I）的取代的吡唑并吡啶-6-胺，包括其立体异构体和/或其药学上可接受的盐。 其中R，R1，R2，Ra，Raa，Rb和n如本文所定义。 本发明还涉及包含式（I）化合物的药物组合物。 本申请的化合物可用作增加HDL胆固醇和降低患者体内LDL胆固醇的CETP抑制剂。