公开(公告)号：US11236142B2

公开(公告)日：2022-02-01

申请号：US16638970

申请日：2018-08-16

申请人： DONG-A ST CO., LTD.

发明人： Jae-Sung Yang ,  Kyung-Seok Lee ,  Yu-Na Chae ,  Gye-Rim Baek ,  Tae-Hyoung Kim ,  Ill-Hun Jung ,  Chae-Lim Ryu ,  Weon-Bin Im

IPC分类号： A61K38/00 ,  C07K14/575 ,  A61P3/04 ,  A61P3/10

摘要： The present invention relates to a novel peptide analog of acylated oxyntomodulin and a pharmaceutical composition comprising the same for preventing and treating obesity or overweightness, or diabetes accompanied by obesity and overweightness. The peptides are superior to those of natural oxyntomodulin in dual agonism on GLP-1 and glucagon receptors and longer in vivo half-life. A pharmaceutical composition comprising said peptides is effective in the treatment of metabolic diseases such as obesity and diabetes mellitus.

公开(公告)号：US11713344B2

公开(公告)日：2023-08-01

申请号：US17410697

申请日：2021-08-24

申请人： DONG-A ST CO., LTD.

发明人： Jae-Sung Yang ,  Kyung-Seok Lee ,  Yu-Na Chae ,  Gye-Rim Baek ,  Tae-Hyoung Kim ,  Ill-Hun Jung ,  Chae-Lim Ryu ,  Weon-Bin Im

IPC分类号： C07K14/575 ,  A61P3/04 ,  A61P3/10 ,  A61K38/00

CPC分类号： C07K14/575 ,  A61P3/04 ,  A61P3/10 ,  A61K38/00

摘要： A novel peptide analog of acylated oxyntomodulin and its uses are disclosed. A pharmaceutical composition containing the novel peptide analog is useful and effective for preventing and treating obesity or overweightness, or diabetes accompanied by obesity and overweightness. The peptide analog and a composition containing the peptide analog are superior to those of wild-type oxyntomodulin in dual agonism on GLP-1 and glucagon receptors and longer in vivo half-life. A pharmaceutical composition containing the peptide analog is effective in the treatment of metabolic diseases such as obesity and diabetes mellitus.