-
公开(公告)号：US11998613B2
公开(公告)日：2024-06-04
申请号：US17339747
申请日：2021-06-04
发明人： Shih-Hsien Chuang , Wei-Ting Sun , Ying-Shuan Lailee , Chun-Liang Lai , Wun-Huei Lin , Win-Yin Wei , Shih-Chong Tsai , Cheng-Chou Yu , Chao-Yang Huang
CPC分类号： A61K47/6851 , A61K47/545 , A61K47/6803 , A61K47/6817 , A61K47/6889 , A61P35/00
摘要： The present disclosure provides an immunoconjugate includes an antibody comprising an antigen-binding fragment that specifically binds to an epitope in mesothelin, N-glycan binding domain and an N-glycan; a linker linking to the N-glycan; and a payload A and a payload B conjugated to the linker, respectively; wherein the payload A and the payload B are the same or different. A pharmaceutical composition comprises the immunoconjugate and a method for treating cancer are also provided in the disclosure.
-
公开(公告)号：US20210015942A1
公开(公告)日：2021-01-21
申请号：US16244090
申请日：2019-01-09
发明人： Shih-Hsien Chuang , Chu-Bin Liao , Wei-Ting Sun , Chen-Hsien Liang , Wun-Huei Lin , Chun-Liang Lai , Her-Sheng Lin
摘要： An immunoconjugate having the Formula Ab-[L1-(A-L2-B)m]n, wherein: (a) Ab is an antibody or a binding fragment thereof; (b) L1 and L2 are each independently a linker, wherein L1 and L2 are the same or different and wherein L1 links to L2; (c) A is a target-protein ligand/binder; (d) B is a ubiquitin ligase ligand/binder, and (e) n and m are independently integers from 1 to 8. The target protein includes kinase, G protein-coupled receptors, transcription factor, phosphatases, and RAS superfamily members.
-
搜索结果
2 条记录 (耗时 0.013 秒)
