专利检索 ap:("DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OFFENTLICHEN RECHTS") AND inv:"Erik FÄSSLER" 第 1 页

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发明申请
ARYL HYDROCARBON RECEPTOR (AHR) ACTIVATION SIGNATURE AND METHODS FOR DETERMINING AHR SIGNALING STATUS 有权

公开(公告)号：US20220195533A1

公开(公告)日：2022-06-23

申请号：US17599681

申请日：2020-03-28

申请人： DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OFFENTLICHEN RECHTS

发明人： Christiane A. OPITZ , Ahmed SADIK , Saskia TRUMP , Soumya R. MOHAPATRA , Sascha SCHÄUBLE , Erik FÄSSLER , Luis F. SOMARRIBAS PATTERSON

IPC分类号： C12Q1/6886 , G16B25/10 , G16B40/20 , G16B40/30

摘要： The present disclosure relates to the generation and uses of an improved set of biomarkers that are aryl hydrocarbon receptor (AHR) target genes, designated as “AHR biomarkers.” The AHR biomarkers described herein allow one to efficiently determine AHR activation groups and sub-groups, in particular for an improved classification of tumors. As used herein, AHR activation groups are called “AHR activation signatures”. The AHR biomarkers comprise markers that are important in diagnosis and therapy, for example for selecting patients for treatment with AHR activation modulating interventions, and monitoring of therapy response.