公开(公告)号：US20170334846A1

公开(公告)日：2017-11-23

申请号：US15524548

申请日：2015-11-03

Applicant: DART NEUROSCIENCE (CAYMAN) LTD.

Inventor： Jillian Basinger ,  Brett Bookser ,  Mi Chen ,  Andrew Hudson ,  James Na ,  Joel Renick ,  Vincent Santora

IPC: C07D205/04 ,  C07D405/10 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D405/14

CPC classification number: C07D205/04 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D405/10 ,  C07D405/14 ,  C07D413/04

Abstract: The invention provides a chemical entity of Formula (I) wherein R1, R2, R3, R4, X, and Y have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive treatments; modulating and treating disorders mediated by GlyT1 activity; treating neurological disorders, CNS disorders, dementia, neurodegenerative diseases, and trauma-dependent losses of function; treating stroke, including cognitive and motor deficits during stroke rehabilitation; facilitating neuroprotection and neurorecovery; enhancing the efficiency of cognitive and motor training, including animal skill training; and treating other disorders, including pain and alcohol-dependence.

公开(公告)号：US09708334B2

公开(公告)日：2017-07-18

申请号：US15306064

申请日：2015-04-22

Applicant: DART NEUROSCIENCE (CAYMAN) LTD.

Inventor： Jillian Basinger ,  Brett Bookser ,  Mi Chen ,  DeMichael Chung ,  Varsha Gupta ,  Andrew Hudson ,  Alan Kaplan ,  James Na ,  Joel Renick ,  Vincent Santora

IPC: C07D471/04 ,  C07D487/04 ,  C07D519/00

CPC classification number: C07D487/04 ,  C07D471/04 ,  C07D519/00

Abstract: The invention provides a chemical entity of Formula (I), wherein R1, R2, R3, R4, R5 and X have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive treatments; modulating and treating disorders mediated by GlyT1 activity; treating neurological disorders, CNS disorders, dementia, neurodegenerative diseases, and trauma-dependent losses of function; treating stroke, including cognitive and motor deficits during stroke rehabilitation; facilitating neuroprotection and neurorecovery; enhancing the efficiency of cognitive and motor training, including animal skill training; and treating other disorders, including pain and alcohol-dependence.

公开(公告)号：US10040759B2

公开(公告)日：2018-08-07

申请号：US15524548

申请日：2015-11-03

Applicant: DART NEUROSCIENCE (CAYMAN) LTD.

Inventor： Jillian Basinger ,  Brett Bookser ,  Mi Chen ,  Andrew Hudson ,  James Na ,  Joel Renick ,  Vincent Santora

IPC: C07D205/04 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D405/10 ,  C07D405/14 ,  A61K31/397 ,  C07D413/04 ,  A61P25/00

Abstract: The invention provides a chemical entity of Formula (I) wherein R1, R2, R3, R4, X, and Y have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive treatments; modulating and treating disorders mediated by GlyT1 activity; treating neurological disorders, CNS disorders, dementia, neurodegenerative diseases, and trauma-dependent losses of function; treating stroke, including cognitive and motor deficits during stroke rehabilitation; facilitating neuroprotection and neurorecovery; enhancing the efficiency of cognitive and motor training, including animal skill training; and treating other disorders, including pain and alcohol-dependence.

公开(公告)号：US20170044167A1

公开(公告)日：2017-02-16

申请号：US15306064

申请日：2015-04-22

Applicant: DART NEUROSCIENCE (CAYMAN) LTD.

Inventor： Jillian Basinger ,  Brett Bookser ,  Mi Chen ,  DeMichael Chung ,  Varsha Gupta ,  Andrew Hudson ,  Alan Kaplan ,  James Na ,  Joel Renick ,  Vincent Santora

IPC: C07D487/04 ,  C07D519/00 ,  C07D471/04

CPC classification number: C07D487/04 ,  C07D471/04 ,  C07D519/00

Abstract: The invention provides a chemical entity of Formula (I), wherein R1, R2, R3, R4, R5 and X have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive treatments; modulating and treating disorders mediated by GlyT1 activity; treating neurological disorders, CNS disorders, dementia, neurodegenerative diseases, and trauma-dependent losses of function; treating stroke, including cognitive and motor deficits during stroke rehabilitation; facilitating neuroprotection and neurorecovery; enhancing the efficiency of cognitive and motor training, including animal skill training; and treating other disorders, including pain and alcohol-dependence.

Abstract translation: 本发明提供式（I）的化学实体，其中R1，R2，R3，R4，R5和X具有本文所述的任何值，以及包含这些化学实体的组合物; 制作方法; 并在广泛的方法中使用，包括代谢和反应动力学研究; 检测和成像技术; 放射治疗; 调节和治疗由GlyT1活性介导的疾病; 治疗神经系统疾病，中枢神经系统疾病，痴呆，神经变性疾病和创伤依赖性功能损失; 治疗中风，包括中风康复期间的认知和运动缺陷; 促进神经保护和神经恢复; 提高认知和运动训练的效率，包括动物技能训练; 并治疗其他疾病，包括疼痛和酒精依赖。