公开(公告)号：US20220324786A1

公开(公告)日：2022-10-13

申请号：US17634600

申请日：2020-08-25

申请人： DANISCO US INC.

发明人： Juho JÄRVINEN ,  Hannu KOIVIKKO ,  Jyrki KUUSISTO ,  Tero Tuomas MENTUNEN ,  Juha NURMI ,  Pertti Matias SÄRELÄ ,  Jani SIITONEN ,  Gregory M. WHITED

IPC分类号： C07C51/43 ,  C12N1/20

摘要： Compositions and methods are provided for producing crystalline forms of organic acids or salts or lactones thereof from an aqueous solution. More specifically, methods are provided for producing a crystalline form of a salt of mevalonic acid (also referred to as X-MVA) from an aqueous solution, comprising subjecting the aqueous solution comprising said X-MVA to a purification step to produce a purified solution and crystallizing said X-MVA from said purified solution by water solvent crystallization. Methods are also provided for producing mevalonolactone from an aqueous solution comprising X-MVA, comprising subjecting the aqueous solution comprising said X-MVA to cation exchange thereby converting said aqueous solution comprising X-MVA to an aqueous solution comprising mevalonolactone (MVL). Methods are also provided for producing mevalonolactone monohydrate crystals.

公开(公告)号：US20220331219A1

公开(公告)日：2022-10-20

申请号：US17634620

申请日：2020-08-25

申请人： DANISCO US INC.

发明人： Heli ANGLENIUS ,  Carole GHERARDI ,  Laura Tiina Maria HUUSKONEN ,  Juho JÄRVINEN ,  Henrik Max JENSEN ,  Hannu KOIVIKKO ,  Jyrki KUUSISTO ,  Tero Tuomas MENTUNEN ,  Juha NURMI ,  Piera Mattia PERICU ,  Pertti Matias SÄRELÄ ,  Jani SIITONEN ,  Kirsti TIIHONEN ,  Gregory M. WHITED

IPC分类号： A61K8/49 ,  A61K8/365 ,  A61Q17/00 ,  A61Q19/00 ,  A61Q19/10 ,  A61Q19/08

摘要： Compositions comprising mevalonolactone, mevalonic add, mevalonate, salts of mevalonic acid, mevalonolactone monohydrate, or any combination thereof and methods of use are provided for topical application for skin care, skin supplement, hair care, and oral care. More specifically, the present disclosure is directed towards compositions comprising mevalonolactone, mevalonic acid, mevalonate, salts of mevalonic acid, mevalonolactone monohydrate, or any combination thereof for providing a skin care benefit and/or multiple skin care benefits.