公开(公告)号：US20240239778A1

公开(公告)日：2024-07-18

申请号：US18414072

申请日：2024-01-16

Applicant: Daiichi Sankyo Company, Limited

Inventor： Keiji Saito ,  Katsuyoshi Nakajima ,  Yasuyuki Ogawa ,  Mitsuhiro Makino ,  Kaori Ito ,  Seiko Nagata ,  Makoto Hirasawa

IPC: C07D413/14 ,  C07D307/94 ,  C07D309/12 ,  C07D405/10 ,  C07D405/14 ,  C07D407/12 ,  C07D413/10 ,  C07D498/10

CPC classification number: C07D413/14 ,  C07D307/94 ,  C07D309/12 ,  C07D405/10 ,  C07D405/14 ,  C07D407/12 ,  C07D413/10 ,  C07D498/10

Abstract: The present invention addresses the problem of providing a compound for prophylaxis and/or treatment of central inflammatory diseases, or a pharmacologically acceptable salt thereof. The present invention addresses a compound of a general formula (I) or a pharmacologically acceptable salt thereof as a means to solve the problem. [R1: a C1-C6 alkyl group or the like, R2: a C1-C6 alkyl group or the like, A: a 5-membered aromatic hetero-ring or the like, R3, R3′: a C1-C6 alkyl group or the like]

公开(公告)号：US20220411416A1

公开(公告)日：2022-12-29

申请号：US17845426

申请日：2022-06-21

Applicant: Daiichi Sankyo Company, Limited

Inventor： Keiji Saito ,  Katsuyoshi Nakajima ,  Yasuyuki Ogawa ,  Mitsuhiro Makino ,  Kaori Ito ,  Seiko Nagata ,  Makoto Hirasawa

IPC: C07D413/14 ,  C07D307/94 ,  C07D309/12 ,  C07D405/10 ,  C07D405/14 ,  C07D407/12 ,  C07D413/10 ,  C07D498/10

Abstract: The present invention addresses the problem of providing a compound for prophylaxis and/or treatment of central inflammatory diseases, or a pharmacologically acceptable salt thereof. The present invention addresses a compound of a general formula (I) or a pharmacologically acceptable salt thereof as a means to solve the problem. [R1: a C1-C6 alkyl group or the like, R2: a C1-C6 alkyl group or the like, A: a 5-membered aromatic hetero-ring or the like, R3, R3′: a C1-C6 alkyl group or the like]

公开(公告)号：US10654821B2

公开(公告)日：2020-05-19

申请号：US16561459

申请日：2019-09-05

Applicant: Daiichi Sankyo Company, Limited

Inventor： Keiji Saito ,  Katsuyoshi Nakajima ,  Toru Taniguchi ,  Osamu Iwamoto ,  Satoshi Shibuya ,  Yasuyuki Ogawa ,  Kazumasa Aoki ,  Nobuya Kurikawa ,  Shinji Tanaka ,  Momoko Ogitani ,  Eriko Kioi ,  Kaori Ito ,  Natsumi Nishihama ,  Tsuyoshi Mikkaichi ,  Wataru Saitoh

IPC: C07D307/94 ,  C07D405/10 ,  C07D413/14 ,  C07D413/10 ,  C07D407/12

Abstract: An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof.The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below: R1: e.g., a C1-C6 alkyl group; R2: a C1-C6 alkyl group; A: e.g., an oxygen atom; and R3: e.g., a C1-C6 alkyl group.

公开(公告)号：US20200002302A1

公开(公告)日：2020-01-02

申请号：US16561459

申请日：2019-09-05

Applicant: Daiichi Sankyo Company, Limited

Inventor： Keiji Saito ,  Katsuyoshi Nakajima ,  Toru Taniguchi ,  Osamu Iwamoto ,  Satoshi Shibuya ,  Yasuyuki Ogawa ,  Kazumasa Aoki ,  Nobuya Kurikawa ,  Shinji Tanaka ,  Momoko Ogitani ,  Eriko Kioi ,  Kaori Ito ,  Natsumi Nishihama ,  Tsuyoshi Mikkaichi ,  Wataru Saitoh

IPC: C07D307/94 ,  C07D405/10 ,  C07D407/12 ,  C07D413/10 ,  C07D413/14

Abstract: An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof.The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below: R1: e.g., a C1-C6 alkyl group; R2: a C1-C6 alkyl group; A: e.g., an oxygen atom; and R3: e.g., a C1-C6 alkyl group.

公开(公告)号：US20230136988A1

公开(公告)日：2023-05-04

申请号：US18046270

申请日：2022-10-13

Applicant: Daiichi Sankyo Company, Limited

Inventor： Keiji Saito ,  Katsuyoshi Nakajima ,  Toru Taniguchi ,  Osamu Iwamoto ,  Satoshi Shibuya ,  Yasuyuki Ogawa ,  Kazumasa Aoki ,  Nobuya Kurikawa ,  Shinji Tanaka ,  Momoko Ogitani ,  Eriko Kioi ,  Kaori Ito ,  Natsumi Nishihama ,  Tsuyoshi Mikkaichi ,  Wataru Saitoh

IPC: C07D307/94 ,  C07D405/04 ,  C07D413/04 ,  A61K31/4155 ,  A61K31/4245 ,  A61K31/343 ,  C07D405/10 ,  C07D407/12 ,  C07D413/10 ,  C07D413/14

Abstract: An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof.
The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below: R1: e.g., a C1-C6 alkyl group; R2: a C1-C6 alkyl group; A: e.g., an oxygen atom; and R3: e.g., a C1-C6 alkyl group.

公开(公告)号：US11472784B2

公开(公告)日：2022-10-18

申请号：US17212373

申请日：2021-03-25

Applicant: Daiichi Sankyo Company, Limited

Inventor： Keiji Saito ,  Katsuyoshi Nakajima ,  Toru Taniguchi ,  Osamu Iwamoto ,  Satoshi Shibuya ,  Yasuyuki Ogawa ,  Kazumasa Aoki ,  Nobuya Kurikawa ,  Shinji Tanaka ,  Momoko Ogitani ,  Eriko Kioi ,  Kaori Ito ,  Natsumi Nishihama ,  Tsuyoshi Mikkaichi ,  Wataru Saitoh

IPC: C07D307/94 ,  C07D405/04 ,  C07D405/10 ,  C07D407/12 ,  C07D413/04 ,  C07D413/10 ,  C07D413/14 ,  A61K31/343 ,  A61K31/4155 ,  A61K31/4245

Abstract: An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof.
The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below: R1: e.g., a C1-C6 alkyl group; R2: a C1-C6 alkyl group; A: e.g., an oxygen atom; and R3: e.g., a C1-C6 alkyl group.

公开(公告)号：US20200216433A1

公开(公告)日：2020-07-09

申请号：US16648570

申请日：2018-09-28

Applicant: Daiichi Sankyo Company, Limited

Inventor： Keiji Saito ,  Katsuyoshi Nakajima ,  Yasuyuki Ogawa ,  Mitsuhiro Makino ,  Kaori Ito ,  Seiko Nagata ,  Hirasawa Makoto

IPC: C07D413/14 ,  C07D307/94 ,  C07D405/10 ,  C07D413/10 ,  C07D309/12 ,  C07D407/12 ,  C07D405/14 ,  C07D498/10

Abstract: The present invention addresses the problem of providing a compound for prophylaxis and/or treatment of central inflammatory diseases, or a pharmacologically acceptable salt thereof. The present invention addresses a compound of a general formula (I) or a pharmacologically acceptable salt thereof as a means to solve the problem. [R1: a C1-C6 alkyl group or the like, R2: a C1-C6 alkyl group or the like, A: a 5-membered aromatic hetero-ring or the like, R3, R3′: a C1-C6 alkyl group or the like]

公开(公告)号：US20250059151A1

公开(公告)日：2025-02-20

申请号：US18819139

申请日：2024-08-29

Applicant: Daiichi Sankyo Company, Limited

Inventor： Keiji Saito ,  Katsuyoshi Nakajima ,  Toru Taniguchi ,  Osamu Iwamoto ,  Satoshi Shibuya ,  Yasuyuki Ogawa ,  Kazumasa Aoki ,  Nobuya Kurikawa ,  Shinji Tanaka ,  Momoko Ogitani ,  Eriko Kioi ,  Kaori Ito ,  Natsumi Nishihama ,  Tsuyoshi Mikkaichi ,  Wataru Saitoh

IPC: C07D307/94 ,  A61K31/343 ,  A61K31/4155 ,  A61K31/4245 ,  C07D405/04 ,  C07D405/10 ,  C07D407/12 ,  C07D413/04 ,  C07D413/10 ,  C07D413/14

Abstract: An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof.
The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below: R1: e.g., a C1-C6 alkyl group; R2: a C1-C6 alkyl group; A: e.g., an oxygen atom; and R3: e.g., a C1-C6 alkyl group.

公开(公告)号：US20240150309A1

公开(公告)日：2024-05-09

申请号：US18501481

申请日：2023-11-03

Applicant: Daiichi Sankyo Company, Limited

Inventor： Keiji Saito ,  Katsuyoshi Nakajima ,  Toru Taniguchi ,  Osamu Iwamoto ,  Satoshi Shibuya ,  Yasuyuki Ogawa ,  Kazumasa Aoki ,  Nobuya Kurikawa ,  Shinji Tanaka ,  Momoko Ogitani ,  Eriko Kioi ,  Kaori Ito ,  Natsumi Nishihama ,  Tsuyoshi Mikkaichi ,  Wataru Saitoh

IPC: C07D307/94 ,  A61K31/343 ,  A61K31/4155 ,  A61K31/4245 ,  C07D405/04 ,  C07D405/10 ,  C07D407/12 ,  C07D413/04 ,  C07D413/10 ,  C07D413/14

CPC classification number: C07D307/94 ,  A61K31/343 ,  A61K31/4155 ,  A61K31/4245 ,  C07D405/04 ,  C07D405/10 ,  C07D407/12 ,  C07D413/04 ,  C07D413/10 ,  C07D413/14

Abstract: An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof.
The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof.




wherein the symbols in the formula are defined below: R1: e.g., a C1-C6 alkyl group; R2: a C1-C6 alkyl group; A: e.g., an oxygen atom; and R3: e.g., a C1-C6 alkyl group.

公开(公告)号：US20230331700A1

公开(公告)日：2023-10-19

申请号：US18057511

申请日：2022-11-21

Applicant: Daiichi Sankyo Company, Limited

Inventor： Toru Taniguchi ,  Osamu Iwamoto ,  Keiji Saito ,  Katsuyoshi Nakajima ,  Yasuyuki Ogawa ,  Nobuya Kurikawa ,  Seiko Nagata ,  Kaori Ito ,  Eriko Kioi

IPC: C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D498/10

CPC classification number: C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D498/10 ,  C07B2200/13

Abstract: An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof.
The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof.




wherein the symbols in the formula are defined below: A: e.g., Benzene, E: e.g., —CH2—, G: e.g., a 5-membered aromatic heterocyclic ring, X: e.g., cyclohexane, J: e.g., a 5-membered aromatic heterocyclic ring, Y: e.g., a phenyl group, R1, R2, R3: e.g., a halogen atom, R4: e.g., a C1-C6 alkyl group, R5: e.g., a hydrogen atom, R6a, R6b, R6c, R6d: e.g., a hydrogen atom, R7: e.g., a hydrogen atom, R8: e.g., a hydrogen atom, n1, n2, n3: e.g., 1.