公开(公告)号：US20250072917A1

公开(公告)日：2025-03-06

申请号：US18288731

申请日：2023-08-18

Applicant: DAEGU CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

Inventor： Sung Won YOUN

IPC: A61B17/22 ,  A61B17/00 ,  A61B17/12

Abstract: A system for removing a thrombus in a blood vessel, includes: a main body part which is movable along the blood vessel and performs a revascularization function within the blood vessel during installation, and sucks and transfers the thrombus during aspiration; a microflow circuit part which is attached to the outer surface of the main body part and extends to the exterior of the body, creates a microflow circuit which acts on the thrombus to move, deform, and fragment the thrombus; and an aspiration part which is provided to the exterior of the body from the inside of the blood vessel, and which during aspiration, after blocking blood flow in the blood vessel, aspirates the thrombus which has been moved, deformed and fragmented by the microflow circuit part and transferred by the main body part and discharges the thrombus to the outside of the body.

公开(公告)号：US20240165127A1

公开(公告)日：2024-05-23

申请号：US18496519

申请日：2023-10-27

Applicant: DAEGU CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

Inventor： Sung Won YOUN ,  Phuong Tu HUYNH ,  Huy Duc VU ,  Jung-hwa RYU

IPC: A61K31/555

CPC classification number: A61K31/555 ,  A61K2123/00

Abstract: There is provided a contrast agent for diagnosis of vascular disease containing a gadolinium-based compound as an active ingredient. It has been found that the gadolinium-based compound Gd-DOTA-click-SF of the present disclosure, has a higher molar longitudinal relaxivity (r1) than Dotarem, is stable, and does not affect in vitro cell viability. In addition, it has been found through MRI images that the specific binding of Gd-DOTA-click-SF in an animal model of abdominal aortic aneurysm established using elastase, a serine protease, is remarkable. Also, it has been confirmed that the content of the gadolinium-based compound of the present disclosure that binds to serine protease in the aorta, that is, the content of gadolinium in the aorta, is remarkable. Thus, the Gd-DOTA-click-SF compound according to the present disclosure may be usefully used in MRI and CT imaging diagnosis for vascular disease.

公开(公告)号：US20220233457A1

公开(公告)日：2022-07-28

申请号：US17512937

申请日：2021-10-28

Applicant: DAEGU CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

Inventor： Sung Won YOUN ,  Huy Duc VU

IPC: A61K9/51 ,  A61K38/17 ,  A23L33/18

Abstract: A method for treating a cerebrovascular disease according to an embodiment of the present disclosure includes administering a composition comprising at least one of melittin and magnetic iron oxide nanoparticle loaded with melittin as an effective component to a subject in need thereof. A composition according to an embodiment of the present disclosure for preventing, ameliorating, or treating a cerebrovascular disease includes melittin or magnetic iron oxide nanoparticle loaded with melittin as an effective component. The melittin or magnetic iron oxide nanoparticle loaded with melittin not only can reduce the diameter of cerebral arteries, increase the thickness of cerebral arteries, increase the content of elastin and smooth muscles, and reduce the content of abnormal collagen but also has an effect of suppressing the expression of the factors which mediate an inflammatory response.