公开(公告)号：US20030216363A1

公开(公告)日：2003-11-20

申请号：US10385936

申请日：2003-03-14

Applicant: Council of Scientific & Industrial Research

Inventor： Ram Pratap ,  Ram Chandra Gupta ,  Ramesh Chander ,  Ashok Kumar Khanna ,  Arvind Kumar Srivastava ,  Deepak Raina ,  Satyavan Singh ,  Savita Srivastava ,  Anil Kumar Rastogi ,  Omkar Prasad Asthana ,  Swarn Nityanand ,  Nitya Anand ,  Ashim Ghatak ,  Narinder Kumar Kapoor ,  Sukh Dev

IPC: A61K031/56

CPC classification number: A61K31/573 ,  C07J13/005 ,  C07J13/007

Abstract: The invention provides a method of using pregnadienones and pregnadienols represented by the structural formula (I) as shown herein below 1 Wherein XnullOH or O or combination thereof and positioning of olefinic bonds are at 4(5); 5(6); 6(17); 17(20) or various combinations and said compounds containing at least one olefinic bond in or on their D-ring for the treatment of hypolipidemic and hypoglycemic conditions in mammals, said method comprising administering an effective amount of the said compounds to the recipient mammals.

Abstract translation: 本发明提供了一种使用由下式结构式（I）表示的孕ad酮和孕二烯醇的方法：其中X = OH或O或其组合，烯键的定位为4（5）; 5（6）; 6（17）; 17（20）或各种组合，并且所述化合物在其D环上或其D环上含有至少一个烯键，用于治疗哺乳动物的降血脂和降血糖病症，所述方法包括向受体哺乳动物施用有效量的所述化合物。