公开(公告)号：US20210008175A1

公开(公告)日：2021-01-14

申请号：US17033195

申请日：2020-09-25

Applicant: ContraFect Corporation

Inventor： Raymond SCHUCH ,  Robert C. NOWINSKI ,  Michael WITTEKIND ,  Han LEE ,  Brent SCHNEIDER

IPC: A61K38/46 ,  C12N9/50 ,  A61K31/4188 ,  A61K31/5377 ,  A61K38/12 ,  A61K38/47 ,  A61K45/06 ,  A61K38/14

Abstract: The present invention provides compositions and methods for prevention, amelioration and treatment of gram positive bacteria, particularly Staphylococcal bacteria, with combinations of lysin, particularly Streptococcal lysin, particularly the lysin PlySs2, and one or more antibiotic, including daptomycin, vancomycin, oxacillin, linezolid, or related antibiotic(s).

公开(公告)号：US20210128696A1

公开(公告)日：2021-05-06

申请号：US17141692

申请日：2021-01-05

Applicant: ContraFect Corporation

Inventor： Raymond SCHUCH ,  Robert C. NOWINSKI ,  Michael WITTEKIND ,  Han LEE ,  Brent SCHNEIDER

IPC: A61K38/46 ,  C12N9/50 ,  A61K31/4188 ,  A61K31/5377 ,  A61K38/12 ,  A61K38/47 ,  A61K45/06 ,  A61K38/14

Abstract: The present invention provides compositions and methods for prevention, amelioration and treatment of gram positive bacteria, particularly Staphylococcal bacteria, with combinations of lysin, particularly Streptococcal lysin, particularly the lysin PlySs2, and one or more antibiotic, including daptomycin, vancomycin, oxacillin, linezolid, or related antibiotic(s).