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公开(公告)号：US20240391952A1
公开(公告)日：2024-11-28
申请号：US18748951
申请日：2024-06-20
Applicant: Chugai Seiyaku Kabushiki Kaisha
Inventor： Tomoyuki Igawa , Zenjiro Sampei , Tetsuya Wakabayashi , Eriko Ito
Abstract: The present invention provides efficient methods based on alteration of the protein A-binding ability, for producing or purifying multispecific antibodies having the activity of binding to two or more types of antigens to high purity through a protein A-based purification step alone. The methods of the present invention for producing or purifying multispecific antibodies which feature altering amino acid residues of antibody heavy chain constant region and/or variable region. Multispecific antibodies with an altered protein A-binding ability, which exhibit plasma retention comparable or longer than that of human IgG1, can be efficiently prepared in high purity by introducing amino acid alterations of the present invention into antibodies.
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公开(公告)号：US20210292360A1
公开(公告)日：2021-09-23
申请号：US17336538
申请日：2021-06-02
Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHA
Inventor： Tomoyuki Igawa , Zenjiro Sampei , Tetsuya Wakabayashi , Eriko Ito
Abstract: The present invention provides efficient methods based on alteration of the protein A-binding ability, for producing or purifying multispecific antibodies having the activity of binding to two or more types of antigens to high purity through a protein A-based purification step alone. The methods of the present invention for producing or purifying multispecific antibodies which feature altering amino acid residues of antibody heavy chain constant region and/or variable region. Multispecific antibodies with an altered protein A-binding ability, which exhibit plasma retention comparable or longer than that of human IgG1, can be efficiently prepared in high purity by introducing amino acid alterations of the present invention into antibodies.
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公开(公告)号：US20240083939A1
公开(公告)日：2024-03-14
申请号：US18505180
申请日：2023-11-09
Applicant: Chugai Seiyaku Kabushiki Kaisha
Inventor： Tomoyuki Igawa , Zenjiro Sampei , Tetsuya Wakabayashi , Eriko Ito
CPC classification number: C07K1/22 , C07K14/70535 , C07K16/2809 , C07K16/2866 , C07K16/303 , C07K16/36 , C07K16/468 , C07K2317/52 , C07K2317/526 , C07K2317/567 , C07K2317/622 , C07K2317/66 , C07K2317/94 , C07K2319/30
Abstract: The present invention provides efficient methods based on alteration of the protein A-binding ability, for producing or purifying multispecific antibodies having the activity of binding to two or more types of antigens to high purity through a protein A-based purification step alone. The methods of the present invention for producing or purifying multispecific antibodies which feature altering amino acid residues of antibody heavy chain constant region and/or variable region. Multispecific antibodies with an altered protein A-binding ability, which exhibit plasma retention comparable or longer than that of human IgG1, can be efficiently prepared in high purity by introducing amino acid alterations of the present invention into antibodies.
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公开(公告)号：US20190352334A1
公开(公告)日：2019-11-21
申请号：US16448088
申请日：2019-06-21
Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHA
Inventor： Tomoyuki Igawa , Zenjiro Sampei , Tetsuya Wakabayashi , Eriko Ito
Abstract: The present invention provides efficient methods based on alteration of the protein A-binding ability, for producing or purifying multispecific antibodies having the activity of binding to two or more types of antigens to high purity through a protein A-based purification step alone. The methods of the present invention for producing or purifying multispecific antibodies which feature altering amino acid residues of antibody heavy chain constant region and/or variable region. Multispecific antibodies with an altered protein A-binding ability, which exhibit plasma retention comparable or longer than that of human IgG1, can be efficiently prepared in high purity by introducing amino acid alterations of the present invention into antibodies.
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公开(公告)号：US20220135618A1
公开(公告)日：2022-05-05
申请号：US17574614
申请日：2022-01-13
Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHA
Inventor： Tomoyuki Igawa , Zenjiro Sampei , Tetsuya Wakabayashi , Eriko Ito
Abstract: The present invention provides efficient methods based on alteration of the protein A-binding ability, for producing or purifying multispecific antibodies having the activity of binding to two or more types of antigens to high purity through a protein A-based purification step alone. The methods of the present invention for producing or purifying multispecific antibodies which feature altering amino acid residues of antibody heavy chain constant region and/or variable region. Multispecific antibodies with an altered protein A-binding ability, which exhibit plasma retention comparable or longer than that of human IgG1, can be efficiently prepared in high purity by introducing amino acid alterations of the present invention into antibodies.
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Patent Agency Ranking
公开(公告)号：US20170275332A1
公开(公告)日：2017-09-28
申请号：US15617008
申请日：2017-06-08
Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHA
Inventor： Tomoyuki Igawa , Zenjiro Sampei , Tetsuya Wakabayashi , Eriko Ito
CPC classification number: C07K1/22 , C07K14/70535 , C07K16/2809 , C07K16/2866 , C07K16/303 , C07K16/36 , C07K16/468 , C07K2317/52 , C07K2317/526 , C07K2317/567 , C07K2317/622 , C07K2317/66 , C07K2317/94 , C07K2319/30
Abstract: The present invention provides efficient methods based on alteration of the protein A-binding ability, for producing or purifying multispecific antibodies having the activity of binding to two or more types of antigens to high purity through a protein A-based purification step alone. The methods of the present invention for producing or purifying multispecific antibodies which feature altering amino acid residues of antibody heavy chain constant region and/or variable region. Multispecific antibodies with an altered protein A-binding ability, which exhibit plasma retention comparable or longer than that of human IgG1, can be efficiently prepared in high purity by introducing amino acid alterations of the present invention into antibodies.
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公开(公告)号：US20230227498A1
公开(公告)日：2023-07-20
申请号：US18193697
申请日：2023-03-31
Applicant: Chugai Seiyaku Kabushiki Kaisha
Inventor： Tomoyuki Igawa , Zenjiro Sampei , Tetsuya Wakabayashi , Eriko Ito
CPC classification number: C07K1/22 , C07K16/2809 , C07K16/2866 , C07K16/303 , C07K16/36 , C07K16/468 , C07K14/70535 , C07K2317/52 , C07K2317/526 , C07K2317/622 , C07K2317/94 , C07K2317/567 , C07K2317/66 , C07K2319/30
Abstract: The present invention provides efficient methods based on alteration of the protein A-binding ability, for producing or purifying multispecific antibodies having the activity of binding to two or more types of antigens to high purity through a protein A-based purification step alone. The methods of the present invention for producing or purifying multispecific antibodies which feature altering amino acid residues of antibody heavy chain constant region and/or variable region. Multispecific antibodies with an altered protein A-binding ability, which exhibit plasma retention comparable or longer than that of human IgG1, can be efficiently prepared in high purity by introducing amino acid alterations of the present invention into antibodies.
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公开(公告)号：US20220389054A1
公开(公告)日：2022-12-08
申请号：US17821494
申请日：2022-08-23
Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHA
Inventor： Tomoyuki Igawa , Zenjiro Sampei , Tetsuya Wakabayashi , Eriko Ito
Abstract: The present invention provides efficient methods based on alteration of the protein A-binding ability, for producing or purifying multispecific antibodies having the activity of binding to two or more types of antigens to high purity through a protein A-based purification step alone. The methods of the present invention for producing or purifying multispecific antibodies which feature altering amino acid residues of antibody heavy chain constant region and/or variable region. Multispecific antibodies with an altered protein A-binding ability, which exhibit plasma retention comparable or longer than that of human IgG1, can be efficiently prepared in high purity by introducing amino acid alterations of the present invention into antibodies.
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公开(公告)号：US20210122812A1
公开(公告)日：2021-04-29
申请号：US17144342
申请日：2021-01-08
Applicant: Chugai Seiyaku Kabushiki Kaisha
Inventor： Tomoyuki Igawa , Naoka Hironiwa , Eriko Ito
Abstract: The present inventors discovered that incorporating an Fc region and an antigen-binding domain whose antigen-binding activity varies depending on ion concentration into an antigen-binding molecule that binds to an aggregate-forming antigen produces an antigen-binding molecule that can preferentially clear protein aggregates in comparison to protein monomers from plasma. Use of antigen-binding molecules of the present invention allows various diseases stemming from target tissues to be treated target-tissue-specifically. Use of antigen-binding molecules of the present invention enables treatment of diseases caused by protein aggregates.
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公开(公告)号：US20210040147A1
公开(公告)日：2021-02-11
申请号：US17076938
申请日：2020-10-22
Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHA
Inventor： Tomoyuki Igawa , Zenjiro Sampei , Tetsuya Wakabayashi , Eriko Ito
Abstract: The present invention provides efficient methods based on alteration of the protein A-binding ability, for producing or purifying multispecific antibodies having the activity of binding to two or more types of antigens to high purity through a protein A-based purification step alone. The methods of the present invention for producing or purifying multispecific antibodies which feature altering amino acid residues of antibody heavy chain constant region and/or variable region. Multispecific antibodies with an altered protein A-binding ability, which exhibit plasma retention comparable or longer than that of human IgG1, can be efficiently prepared in high purity by introducing amino acid alterations of the present invention into antibodies.
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