公开(公告)号：US11912719B2

公开(公告)日：2024-02-27

申请号：US17565231

申请日：2021-12-29

Applicant: Cervello Therapeutics LLC

Inventor： Matthew Randolph Lee ,  Anthony Joseph Varano, Jr. ,  Thomas P. Bobinski

IPC: A61K31/4725 ,  C07D217/22 ,  C07D498/08 ,  C07D401/12 ,  C07D405/14 ,  C07D471/04 ,  C07D403/12

CPC classification number: C07D498/08 ,  C07D401/12 ,  C07D403/12 ,  C07D405/14 ,  C07D471/04

Abstract: The present invention relates to indoline-based compounds that inhibit Rho-associated protein kinase (ROCK) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of inhibiting ROCK activity and methods for treating, for example cerebral cavernous malformation syndrome (CCM) and cardiovascular diseases using the compounds and pharmaceutical compositions of the present invention.

公开(公告)号：US20200140412A1

公开(公告)日：2020-05-07

申请号：US16676044

申请日：2019-11-06

Applicant: Cervello Therapeutics LLC

Inventor： Matthew Randolph Lee ,  Anthony Joseph Varano, JR.

IPC: C07D401/12 ,  C07D471/04 ,  C07D403/12

Abstract: The present invention relates to compounds that inhibit ROCK activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of inhibiting ROCK activity and methods for treating, for example cerebral cavernous malformation syndrome (CCM) and cardiovascular diseases using the compounds and pharmaceutical compositions of the present invention.

公开(公告)号：US10745381B2

公开(公告)日：2020-08-18

申请号：US16676044

申请日：2019-11-06

Applicant: Cervello Therapeutics LLC

Inventor： Matthew Randolph Lee ,  Anthony Joseph Varano, Jr.

IPC: A61K31/4725 ,  A61K31/502 ,  C07D217/24 ,  C07D237/32 ,  C07D401/12 ,  C07D403/12 ,  C07D471/04

Abstract: The present invention relates to indoline-based compounds that inhibit Rho-associated protein kinase (ROCK) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of inhibiting ROCK activity and methods for treating, for example cerebral cavernous malformation syndrome (CCM) and cardiovascular diseases using the compounds and pharmaceutical compositions of the present invention.

公开(公告)号：US20220119406A1

公开(公告)日：2022-04-21

申请号：US17565231

申请日：2021-12-29

Applicant: Cervello Therapeutics LLC

Inventor： Matthew Randolph Lee ,  Anthony Joseph Varano, JR. ,  Thomas P. Bobinski

IPC: C07D498/08 ,  C07D401/12 ,  C07D405/14 ,  C07D471/04 ,  C07D403/12

Abstract: The present invention relates to indoline-based compounds that inhibit Rho-associated protein kinase (ROCK) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of inhibiting ROCK activity and methods for treating, for example cerebral cavernous malformation syndrome (CCM) and cardiovascular diseases using the compounds and pharmaceutical compositions of the present invention.

公开(公告)号：US11248004B2

公开(公告)日：2022-02-15

申请号：US16867162

申请日：2020-05-05

Applicant: Cervello Therapeutics LLC

Inventor： Matthew Randolph Lee ,  Anthony Joseph Varano, Jr. ,  Thomas P. Bobinski

IPC: A61K31/4725 ,  C07D217/22 ,  C07D498/08 ,  C07D401/12 ,  C07D405/14 ,  C07D471/04 ,  C07D403/12

Abstract: The present invention relates to indoline-based compounds that inhibit Rho-associated protein kinase (ROCK) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of inhibiting ROCK activity and methods for treating, for example cerebral cavernous malformation syndrome (CCM) and cardiovascular diseases using the compounds and pharmaceutical compositions of the present invention.

公开(公告)号：US20200262844A1

公开(公告)日：2020-08-20

申请号：US16867162

申请日：2020-05-05

Applicant: Cervello Therapeutics LLC

Inventor： Matthew Randolph Lee ,  Anthony Joseph Varano, JR. ,  Thomas P. Bobinski

IPC: C07D498/08 ,  C07D401/12 ,  C07D403/12 ,  C07D471/04 ,  C07D405/14

Abstract: The present invention relates to compounds that inhibit ROCK activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of inhibiting ROCK activity and methods for treating, for example cerebral cavernous malformation syndrome (CCM) and cardiovascular diseases using the compounds and pharmaceutical compositions of the present invention.