公开(公告)号：US11084810B2

公开(公告)日：2021-08-10

申请号：US16749412

申请日：2020-01-22

申请人： Centrexion Therapeutics Corporation

发明人： Doris Riether ,  Florian Paul Christian Binder ,  Henri Doods ,  Stephan Georg Mueller ,  Janet Rachel Nicholson ,  Achim Sauer

IPC分类号： C07D417/12 ,  C07D413/12 ,  C07D261/14 ,  C07D413/14 ,  C07D413/02 ,  C07D261/04 ,  A61K31/422

摘要： This invention relates to novel (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles and their use as CB2 cannabinoid receptor agonists, pharmaceutical compositions containing the same, and their use for the treatment of CB2 receptor mediated disorders or conditions.

公开(公告)号：US20170320868A1

公开(公告)日：2017-11-09

申请号：US15491035

申请日：2017-04-19

申请人： Centrexion Therapeutics Corporation

发明人： Doris Riether ,  Florian Paul Christian Binder ,  Henri Doods ,  Stephan Georg Mueller ,  Janet Rachel Nicholson ,  Achim Sauer

IPC分类号： C07D417/12 ,  C07D413/02 ,  C07D261/04 ,  C07D261/14 ,  C07D413/14 ,  C07D413/12

CPC分类号： C07D417/12 ,  C07D261/04 ,  C07D261/14 ,  C07D413/02 ,  C07D413/12 ,  C07D413/14

摘要： This invention relates to novel (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles and their use as CB2 cannabinoid receptor agonists, pharmaceutical compositions containing the same, and their use for the treatment of CB2 receptor mediated disorders or conditions.

公开(公告)号：US20220135554A1

公开(公告)日：2022-05-05

申请号：US17398155

申请日：2021-08-10

申请人： Centrexion Therapeutics Corporation

发明人： Doris Riether ,  Florian Paul Christian Binder ,  Henri Doods ,  Stephan Georg Mueller ,  Janet Rachel Nicholson ,  Achim Sauer

IPC分类号： C07D417/12 ,  C07D261/04 ,  C07D261/14 ,  C07D413/02 ,  A61K31/422 ,  C07D413/14 ,  C07D413/12

摘要： This invention relates to novel (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles and their use as CB2 cannabinoid receptor agonists, pharmaceutical compositions containing the same, and their use for the treatment of CB2 receptor mediated disorders or conditions.

公开(公告)号：US10570125B2

公开(公告)日：2020-02-25

申请号：US16143523

申请日：2018-09-27

申请人： Centrexion Therapeutics Corporation

发明人： Doris Riether ,  Florian Paul Christian Binder ,  Henri Doods ,  Stephan Georg Mueller ,  Janet Rachel Nicholson ,  Achim Sauer

IPC分类号： C07D417/12 ,  C07D413/12 ,  C07D261/14 ,  C07D413/14 ,  C07D413/02 ,  C07D261/04

摘要： This invention relates to novel (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles and their use as CB2 cannabinoid receptor agonists, pharmaceutical compositions containing the same, and their use for the treatment of CB2 receptor mediated disorders or conditions.

公开(公告)号：US10112934B2

公开(公告)日：2018-10-30

申请号：US15491035

申请日：2017-04-19

申请人： Centrexion Therapeutics Corporation

发明人： Doris Riether ,  Florian Paul Christian Binder ,  Henri Doods ,  Stephan Georg Mueller ,  Janet Rachel Nicholson ,  Achim Sauer

IPC分类号： A61K31/422 ,  C07D417/12 ,  C07D413/12 ,  C07D261/14 ,  C07D413/14 ,  C07D413/02 ,  C07D261/04

摘要： This invention relates to novel (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles and their use as CB2 cannabinoid receptor agonists, pharmaceutical compositions containing the same, and their use for the treatment of CB2 receptor mediated disorders or conditions.

公开(公告)号：US20240092769A1

公开(公告)日：2024-03-21

申请号：US18216669

申请日：2023-06-30

申请人： Centrexion Therapeutics Corporation

发明人： Doris Riether ,  Florian Paul Christian Binder ,  Henri Doods ,  Stephan George Mueller ,  Janet Rachel Nicholson ,  Achim Sauer

IPC分类号： C07D417/12 ,  A61K31/422 ,  C07D261/04 ,  C07D261/14 ,  C07D413/02 ,  C07D413/12 ,  C07D413/14

CPC分类号： C07D417/12 ,  A61K31/422 ,  C07D261/04 ,  C07D261/14 ,  C07D413/02 ,  C07D413/12 ,  C07D413/14

摘要： This invention relates to novel (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles and their use as CB2 cannabinoid receptor agonists, pharmaceutical compositions containing the same, and their use for the treatment of CB2 receptor mediated disorders or conditions.

公开(公告)号：US20200262830A1

公开(公告)日：2020-08-20

申请号：US16749412

申请日：2020-01-22

申请人： Centrexion Therapeutics Corporation

发明人： Doris Riether ,  Florian Paul Christian Binder ,  Henri Doods ,  Stephan Georg Mueller ,  Janet Rachel Nicholson ,  Achim Sauer

IPC分类号： C07D417/12 ,  C07D261/04 ,  C07D413/02 ,  C07D413/14 ,  C07D261/14 ,  C07D413/12

摘要： This invention relates to novel (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles and their use as CB2 cannabinoid receptor agonists, pharmaceutical compositions containing the same, and their use for the treatment of CB2 receptor mediated disorders or conditions.

公开(公告)号：US11725004B2

公开(公告)日：2023-08-15

申请号：US17398155

申请日：2021-08-10

申请人： Centrexion Therapeutics Corporation

发明人： Doris Riether ,  Florian Paul Christian Binder ,  Henri Doods ,  Stephan Georg Mueller ,  Janet Rachel Nicholson ,  Achim Sauer

IPC分类号： C07D417/12 ,  C07D413/12 ,  C07D261/14 ,  C07D413/14 ,  C07D413/02 ,  C07D261/04 ,  A61K31/422

CPC分类号： C07D417/12 ,  A61K31/422 ,  C07D261/04 ,  C07D261/14 ,  C07D413/02 ,  C07D413/12 ,  C07D413/14

摘要： This invention relates to novel (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles and their use as CB2 cannabinoid receptor agonists, pharmaceutical compositions containing the same, and their use for the treatment of CB2 receptor mediated disorders or conditions.

公开(公告)号：US20190161481A1

公开(公告)日：2019-05-30

申请号：US16143523

申请日：2018-09-27

申请人： Centrexion Therapeutics Corporation

发明人： Doris Riether ,  Florian Paul Christian Binder ,  Henri Doods ,  Stephan Georg Mueller ,  Janet Rachel Nicholson ,  Achim Sauer

IPC分类号： C07D417/12 ,  C07D261/04 ,  C07D413/02 ,  C07D413/12 ,  C07D261/14 ,  C07D413/14

CPC分类号： C07D417/12 ,  C07D261/04 ,  C07D261/14 ,  C07D413/02 ,  C07D413/12 ,  C07D413/14

摘要： This invention relates to novel (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles and their use as CB2 cannabinoid receptor agonists, pharmaceutical compositions containing the same, and their use for the treatment of CB2 receptor mediated disorders or conditions.

公开(公告)号：US09650370B2

公开(公告)日：2017-05-16

申请号：US14891051

申请日：2014-05-16

申请人： Centrexion Therapeutics Corporation

发明人： Doris Riether ,  Florian Paul Christian Binder ,  Henri Doobs ,  Stephan Georg Mueller ,  Janet Rachel Nicholson ,  Achim Sauer

IPC分类号： C07D417/12 ,  C07D413/12 ,  C07D261/14 ,  C07D413/14 ,  C07D413/02 ,  C07D261/04

CPC分类号： C07D417/12 ,  C07D261/04 ,  C07D261/14 ,  C07D413/02 ,  C07D413/12 ,  C07D413/14

摘要： This invention relates to novel (Cyano-dimethyl-methyl)-isoxazolesand-[1,3,4]thiadiazoles and their use as CB2 cannabinoid receptor agonists, pharmaceutical compositions containing the same, and their use for the treatment of CB2 receptor mediated disorders or conditions.