公开(公告)号：US20210000743A1

公开(公告)日：2021-01-07

申请号：US16310585

申请日：2017-06-28

Applicant: Celltrion Inc.

Inventor： Joon Won Lee ,  Won Yong Han ,  Su Jung Kim ,  Jun Seok Oh ,  So Young Kim ,  Su Hyeon Hong ,  Yeon Kyeong Shin

IPC: A61K9/08 ,  C07K16/24 ,  A61K47/10 ,  A61K47/26 ,  A61K47/18

Abstract: The present invention provides a stable liquid pharmaceutical formulation containing: an antibody or its antigen-binding fragment; a surfactant; a sugar or its derivative; and a buffer. The stable liquid pharmaceutical formulation according to the present invention has low viscosity while containing a high content of the antibody, has excellent long-term storage stability based on excellent stability under accelerated conditions and severe conditions, and may be administered subcutaneously.

公开(公告)号：US20240269071A1

公开(公告)日：2024-08-15

申请号：US18593012

申请日：2024-03-01

Applicant: Celltrion Inc.

Inventor： Joon Won Lee ,  Won Yong Han ,  Su Jung Kim ,  Jun Seok Oh ,  So Young Kim ,  Su Hyeon Hong ,  Yeon Kyeong Shin

IPC: A61K9/08 ,  A61K39/00 ,  A61K39/395 ,  A61K47/10 ,  A61K47/18 ,  A61K47/26 ,  A61P37/02 ,  A61P37/04 ,  A61P37/06 ,  C07K16/00 ,  C07K16/24

CPC classification number: A61K9/08 ,  A61K39/00 ,  A61K39/395 ,  A61P37/02 ,  A61P37/04 ,  A61P37/06 ,  C07K16/00 ,  C07K16/241 ,  A61K2039/505 ,  A61K47/10 ,  A61K47/183 ,  A61K47/26 ,  C07K2317/622

Abstract: The present invention provides a stable liquid pharmaceutical formulation containing: an antibody or its antigen-binding fragment; a surfactant; a sugar or its derivative; and a buffer. The stable liquid pharmaceutical formulation according to the present invention has low viscosity while containing a high content of the antibody, has excellent long-term storage stability based on excellent stability under accelerated conditions and severe conditions, and may be administered subcutaneously.

公开(公告)号：US20240269069A1

公开(公告)日：2024-08-15

申请号：US18434346

申请日：2024-02-06

Applicant: Celltrion Inc.

Inventor： Joon Won Lee ,  Won Yong Han ,  Su Jung Kim ,  Jun Seok Oh ,  So Young Kim ,  Su Hyeon Hong ,  Yeon Kyeong Shin

IPC: A61K9/08 ,  A61K39/00 ,  A61K39/395 ,  A61K47/10 ,  A61K47/18 ,  A61K47/26 ,  A61P37/02 ,  A61P37/04 ,  A61P37/06 ,  C07K16/00 ,  C07K16/24

CPC classification number: A61K9/08 ,  A61K39/00 ,  A61K39/395 ,  A61P37/02 ,  A61P37/04 ,  A61P37/06 ,  C07K16/00 ,  C07K16/241 ,  A61K2039/505 ,  A61K47/10 ,  A61K47/183 ,  A61K47/26 ,  C07K2317/622

Abstract: The present invention provides a stable liquid pharmaceutical formulation containing: an antibody or its antigen-binding fragment; a surfactant; a sugar or its derivative; and a buffer. The stable liquid pharmaceutical formulation according to the present invention has low viscosity while containing a high content of the antibody, has excellent long-term storage stability based on excellent stability under accelerated conditions and severe conditions, and may be administered subcutaneously.

公开(公告)号：US11951207B2

公开(公告)日：2024-04-09

申请号：US16310585

申请日：2017-06-28

Applicant: Celltrion Inc.

Inventor： Joon Won Lee ,  Won Yong Han ,  Su Jung Kim ,  Jun Seok Oh ,  So Young Kim ,  Su Hyeon Hong ,  Yeon Kyeong Shin

IPC: A61K9/08 ,  A61K39/00 ,  A61K39/395 ,  A61P37/02 ,  A61P37/04 ,  A61P37/06 ,  C07K16/00 ,  C07K16/24 ,  A61K47/10 ,  A61K47/18 ,  A61K47/26

CPC classification number: A61K9/08 ,  A61K39/00 ,  A61K39/395 ,  A61P37/02 ,  A61P37/04 ,  A61P37/06 ,  C07K16/00 ,  C07K16/241 ,  A61K2039/505 ,  A61K47/10 ,  A61K47/183 ,  A61K47/26 ,  C07K2317/622

Abstract: The present invention provides a stable liquid pharmaceutical formulation containing: an antibody or its antigen-binding fragment; a surfactant; a sugar or its derivative; and a buffer. The stable liquid pharmaceutical formulation according to the present invention has low viscosity while containing a high content of the antibody, has excellent long-term storage stability based on excellent stability under accelerated conditions and severe conditions, and may be administered subcutaneously.