公开(公告)号：US20170320839A1

公开(公告)日：2017-11-09

申请号：US15406128

申请日：2017-01-13

申请人： Celgene International II Sàrl

发明人： Esther Martinborough ,  Marcus F. Boehm ,  Adam Richard Yeager ,  Junko Tamiya ,  Liming Huang ,  Enugurthi Brahmachary ,  Manisha Moorjani ,  Gregg Alan Timony ,  Jennifer L. Brooks ,  Robert Peach ,  Fiona Lorraine Scott ,  Michael Allen Hanson

IPC分类号： C07D271/06 ,  C07D413/14 ,  C07D413/12 ,  C07D413/10 ,  C07C311/13 ,  C07C245/14 ,  A61K31/4245 ,  A61K45/06 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/454 ,  A61K31/427 ,  C07D417/12 ,  C07C255/58

CPC分类号： C07D271/06 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06 ,  C07C245/14 ,  C07C255/58 ,  C07C311/13 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

摘要： Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

公开(公告)号：US10239846B2

公开(公告)日：2019-03-26

申请号：US15406128

申请日：2017-01-13

申请人： Celgene International II Sàrl

发明人： Esther Martinborough ,  Marcus F. Boehm ,  Adam Richard Yeager ,  Junko Tamiya ,  Liming Huang ,  Enugurthi Brahmachary ,  Manisha Moorjani ,  Gregg Alan Timony ,  Jennifer L. Brooks ,  Robert Peach ,  Fiona Lorraine Scott ,  Michael Allen Hanson

IPC分类号： A61K31/4245 ,  A61K45/06 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/454 ,  A61K31/427 ,  C07D271/06 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07C245/14 ,  C07C255/58 ,  C07C311/13

摘要： Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.