公开(公告)号：US11185543B2

公开(公告)日：2021-11-30

申请号：US16859357

申请日：2020-04-27

Applicant: Celgene Corporation

Inventor： Matthew D. Alexander ,  Gerald D. Artman, III ,  James Carmichael ,  Brian E. Cathers ,  Matthew D. Correa ,  Joshua Hansen ,  Courtney G. Havens ,  Timothy S. Kercher ,  Antonia Lopez-Girona ,  Xiaoling Lu ,  Hon-Wah Man ,  Mark A. Nagy ,  Joseph R. Piccotti ,  Daniel W. Pierce ,  Paula A. Tavares-Greco ,  Brandon W. Whitefield ,  Lilly L. Wong ,  Nanfei Zou

IPC: A61K31/496 ,  C07D401/04 ,  A61K31/573 ,  A61P35/02 ,  A61K38/05 ,  A61P35/00 ,  A61K31/69

Abstract: Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.

公开(公告)号：US20240207255A1

公开(公告)日：2024-06-27

申请号：US18419894

申请日：2024-01-23

Applicant: Celgene Corporation

Inventor： Matthew D. Alexander ,  Gerald D. Artman ,  Gordon L. Bray ,  James Carmichael ,  Soraya Carranico ,  Brian E. Cathers ,  Matthew D. Correa ,  Joshua Hansen ,  Courtney G. Havens ,  Timothy S. Kercher ,  Antonia Lopez-Girona ,  Xiaoling Lu ,  Hon-Wah Man ,  Mark A. Nagy ,  Rama K. Narla ,  Joseph R. Piccotti ,  Daniel W. Pierce ,  Paula A. Tavares-Greco ,  Brandon W. Whitefield ,  Lilly L. Wong ,  Nanfei Zou

IPC: A61K31/496 ,  A61K31/573 ,  A61K31/69 ,  A61K38/05 ,  A61P35/00 ,  A61P35/02 ,  C07D401/04

CPC classification number: A61K31/496 ,  A61K31/573 ,  A61K38/05 ,  A61P35/00 ,  A61P35/02 ,  C07D401/04 ,  A61K31/69 ,  A61K2300/00

Abstract: Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.

公开(公告)号：US20220280505A1

公开(公告)日：2022-09-08

申请号：US17521432

申请日：2021-11-08

Applicant: Celgene Corporation

Inventor： Matthew D. Alexander ,  Gerald D. Artman, III ,  Gordon L. Bray ,  James Carmichael ,  Soraya Carrancio ,  Brian E. Cathers ,  Matthew D. Correa ,  Joshua Hansen ,  Courtney G. Havens ,  Timothy S. Kercher ,  Antonia Lopez-Girona ,  Xiaoling Lu ,  Hon-Wah Man ,  Mark A. Nagy ,  Rama K. Narla ,  Joseph R. Piccotti ,  Daniel W. Pierce ,  Paula A. Tavares-Greco ,  Brandon W. Whitefield ,  Lilly L. Wong ,  Nanfei Zou

IPC: A61K31/496 ,  A61P35/02 ,  A61K31/573 ,  A61K38/05 ,  C07D401/04 ,  A61P35/00

Abstract: Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.

公开(公告)号：US20200253964A1

公开(公告)日：2020-08-13

申请号：US16859357

申请日：2020-04-27

Applicant: Celgene Corporation

Inventor： Matthew D. Alexander ,  Gerald D. Artman, III ,  Gordon L. Bray ,  James Carmichael ,  Soraya Carrancio ,  Brian E. Cathers ,  Matthew D. Correa ,  Joshua Hansen ,  Courtney G. Havens ,  Timothy S. Kercher ,  Antonia Lopez-Girona ,  Xiaoling Lu ,  Hon-Wah Man ,  Mark A. Nagy ,  Rama K. Narla ,  Joseph R. Piccotti ,  Daniel W. Pierce ,  Paula A. Tavares-Greco ,  Brandon W. Whitefield ,  Lilly L. Wong ,  Nanfei Zou

IPC: A61K31/496 ,  A61P35/00 ,  C07D401/04 ,  A61K38/05 ,  A61K31/573 ,  A61P35/02

Abstract: Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.

公开(公告)号：US20190008852A1

公开(公告)日：2019-01-10

申请号：US16030695

申请日：2018-07-09

Applicant: Celgene Corporation

Inventor： Matthew D. Alexander ,  Gerald D. Artman, III ,  Gordon L. Bray ,  James Carmichael ,  Soraya Carrancio ,  Brian E. Cathers ,  Matthew D. Correa ,  Joshua Hansen ,  Courtney G. Havens ,  Timothy S. Kercher ,  Antonia Lopez-Girona ,  Xiaoling Lu ,  Hon-Wah Man ,  Mark A. Nagy ,  Rama K. Narla ,  Joseph R. Piccotti ,  Daniel W. Pierce ,  Paula A. Tavares-Greco ,  Brandon W. Whitefield ,  Lilly L. Wong ,  Nanfei Zou

IPC: A61K31/496 ,  A61P35/02

CPC classification number: A61K31/496 ,  A61K31/573 ,  A61K31/69 ,  A61K38/05 ,  A61K2300/00 ,  A61P35/00 ,  A61P35/02 ,  C07D401/04

Abstract: Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.

公开(公告)号：US12029738B2

公开(公告)日：2024-07-09

申请号：US17521432

申请日：2021-11-08

Applicant: Celgene Corporation

Inventor： Matthew D. Alexander ,  Gerald D. Artman ,  Gordon L. Bray ,  James Carmichael ,  Soraya Carrancio ,  Brian E. Cathers ,  Matthew D. Correa ,  Joshua Hansen ,  Courtney G. Havens ,  Timothy S. Kercher ,  Antonia Lopez-Girona ,  Xiaoling Lu ,  Hon-Wah Man ,  Mark A. Nagy ,  Rama K. Narla ,  Joseph R. Piccotti ,  Daniel W. Pierce ,  Paula A. Tavares-Greco ,  Brandon W. Whitefield ,  Lilly L. Wong ,  Nanfei Zou

IPC: A61K31/496 ,  A61K31/573 ,  A61K38/05 ,  A61P35/00 ,  A61P35/02 ,  C07D401/04 ,  A61K31/69

CPC classification number: A61K31/496 ,  A61K31/573 ,  A61K38/05 ,  A61P35/00 ,  A61P35/02 ,  C07D401/04 ,  A61K31/69 ,  A61K2300/00 ,  A61K31/496 ,  A61K2300/00 ,  A61K31/573 ,  A61K2300/00 ,  A61K38/05 ,  A61K2300/00

Abstract: Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.

公开(公告)号：US20190282567A1

公开(公告)日：2019-09-19

申请号：US16430189

申请日：2019-06-03

Applicant: Celgene Corporation

Inventor： Matthew D. Alexander ,  Gerald D. Artman, III ,  Gordon L. Bray ,  James Carmichael ,  Soraya Carrancio ,  Brian E. Cathers ,  Matthew D. Correa ,  Joshua Hansen ,  Courtney G. Havens ,  Timothy S. Kercher ,  Antonia Lopez-Girona ,  Xiaoling Lu ,  Hon-Wah Man ,  Mark A. Nagy ,  Rama K. Narla ,  Joseph R. Piccotti ,  Daniel W. Pierce ,  Paula A. Tavares-Greco ,  Brandon W. Whitefield ,  Lilly L. Wong ,  Nanfei Zou

IPC: A61K31/496 ,  C07D401/04 ,  A61K31/573 ,  A61P35/02 ,  A61K38/05 ,  A61P35/00

Abstract: Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.

公开(公告)号：US10357489B2

公开(公告)日：2019-07-23

申请号：US16030695

申请日：2018-07-09

Applicant: Celgene Corporation

Inventor： Matthew D. Alexander ,  Gerald D. Artman, III ,  James Carmichael ,  Brian E. Cathers ,  Matthew D. Correa ,  Joshua Hansen ,  Courtney G. Havens ,  Timothy S. Kercher ,  Antonia Lopez-Girona ,  Xiaoling Lu ,  Hon-Wah Man ,  Mark A. Nagy ,  Joseph R. Piccotti ,  Daniel W. Pierce ,  Paula A. Tavares-Greco ,  Brandon W. Whitefield ,  Lilly L. Wong ,  Nanfei Zou

IPC: C07D241/04 ,  C07D295/00 ,  A61K31/496 ,  A61P35/02 ,  A61K31/573 ,  A61K38/05 ,  C07D401/04 ,  A61P35/00 ,  A61K31/69

Abstract: Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.

公开(公告)号：US20190030018A1

公开(公告)日：2019-01-31

申请号：US16024581

申请日：2018-06-29

Applicant: Celgene Corporation

Inventor： Tonia J. Buchholz ,  James Carmichael ,  Soraya Carrancio ,  Jinhong Fan ,  Rajan Gupta ,  Gang Lu ,  Kyle MacBeth ,  Emily Pace ,  Daniel Pierce ,  Michael Pourdehnad ,  Yu Pu ,  Peng Wang ,  Naijun Wu ,  Sheena Yao

IPC: A61K31/454 ,  A61K47/40 ,  A61K9/00 ,  A61K45/06 ,  A61K31/436 ,  A61K9/19 ,  A61P35/02

Abstract: Provided herein are formulations and methods of use of 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide or a stereoisomer or mixture of stereoisomers, pharmaceutically acceptable salt, tautomer, prodrug, solvate, hydrate, co-crystal, clathrate, or polymorph thereof.