公开(公告)号：US10543212B2

公开(公告)日：2020-01-28

申请号：US15933889

申请日：2018-03-23

申请人： Cardurion Pharmaceuticals, LLC

发明人： Nobuyuki Matsunaga ,  Takashi Nakahata ,  Yuta Tanaka ,  Hiroki Takahagi ,  Yasufumi Miyamoto ,  Rei Okamoto ,  Takeshi Yoshikawa ,  Yoshito Terao ,  Takafumi Yukawa ,  Keiko Kakegawa ,  Yoichi Nishikawa ,  Terufumi Takagi ,  Masashi Takahashi ,  Mallareddy Komandla ,  Lily Kwok ,  Joanne Miura ,  Mark Sabat ,  Nicholas Scorah ,  Paul Tanis ,  John Tyhonas ,  Phong H. Vu ,  Haixia Wang ,  Xiaolun Wang ,  Junya Shirai ,  Tomohiro Okawa ,  Zenyu Shiokawa ,  Akito Shibuya

IPC分类号： C07C211/39 ,  A61K31/506 ,  A61P9/06 ,  A61K31/5377

摘要： The present invention provides a compound having a CaMKII inhibitory action, which is expected to be useful as an agent for the prophylaxis or treatment of cardiac diseases (particularly catecholaminergic polymorphic ventricular tachycardia, postoperative atrial fibrillation, heart failure, fatal arrhythmia) and the like.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US11197858B2

公开(公告)日：2021-12-14

申请号：US16773730

申请日：2020-01-27

申请人： Cardurion Pharmaceuticals, LLC

发明人： Nobuyuki Matsunaga ,  Takashi Nakahata ,  Yuta Tanaka ,  Hiroki Takahagi ,  Yasufumi Miyamoto ,  Rei Okamoto ,  Takeshi Yoshikawa ,  Yoshito Terao ,  Takafumi Yukawa ,  Keiko Kakegawa ,  Yoichi Nishikawa ,  Terufumi Takagi ,  Masashi Takahashi ,  Mallareddy Komandla ,  Lily Kwok ,  Joanne Miura ,  Mark Sabat ,  Nicholas Scorah ,  Paul Tanis ,  John Tyhonas ,  Phong H. Vu ,  Haixia Wang ,  Xiaolun Wang ,  Junya Shirai ,  Tomohiro Okawa ,  Zenyu Shiokawa ,  Akito Shibuya

IPC分类号： C07C211/39 ,  A61K31/506 ,  A61P9/06 ,  A61K31/5377

摘要： The present invention provides a compound having a CaMKII inhibitory action, which is expected to be useful as an agent for the prophylaxis or treatment of cardiac diseases (particularly catecholaminergic polymorphic ventricular tachycardia, postoperative atrial fibrillation, heart failure, fatal arrhythmia) and the like.
The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US11130752B2

公开(公告)日：2021-09-28

申请号：US16580984

申请日：2019-09-24

申请人： Cardurion Pharmaceuticals, LLC

发明人： Nobuyuki Matsunaga ,  Yasufumi Miyamoto ,  Junya Shirai ,  Takashi Nakahata ,  Zenyu Shiokawa ,  Tomohiro Okawa ,  Akito Shibuya ,  Malcolm MacCoss

IPC分类号： C07D401/14 ,  A61K31/505 ,  A61P9/00 ,  C07D413/14 ,  C07D417/14 ,  C07D498/08

摘要： The present invention provides a compound having a CaMKII inhibitory action, which is expected to be useful as an agent for the prophylaxis or treatment of cardiac diseases (particularly catecholaminergic polymorphic ventricular tachycardia, postoperative atrial fibrillation, heart failure, fatal arrhythmia) and the like.
The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.