公开(公告)号：US20230045929A1

公开(公告)日：2023-02-16

申请号：US17773197

申请日：2020-10-30

申请人： Cancer Research Technology Limited

发明人： Mairi SIME ,  Justin BOWER ,  Duncan MCARTHUR ,  Angelo PUGLIESE

IPC分类号： C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12

摘要： Provided are compounds of the Formula I, and salts and solvates thereof: (I) wherein R1, R2, R3, X1, X2, X3 and Z are defined in the specification. The compounds are inhibitors of salt-inducible kinase (SIK), particular SIK2, and are useful in therapy, particularly in the treatment of a proliferative disorder, a benign neoplasm, pathological angiogenesis, an inflammatory disease or condition, a musculoskeletal disease or condition, an autoimmune disease, a haematological disease or condition, a neurological disease or condition, a psychiatric disorder, or a metabolic disorder.