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公开(公告)号：US11136331B2
公开(公告)日：2021-10-05
申请号：US16755719
申请日：2018-10-12
Applicant: Cambrex Charles City, Inc.
Inventor： Par Holmberg , Lars Eklund , David Adams , Michael Letourneau , Margus Eek , Alo Soone
IPC: C07D489/12 , A61K31/485
Abstract: There is provided a novel process for the preparation of a compound of formula I, wherein R1, R2, W, Z and are as described in the description, by demethylation of a corresponding O-methyl derivative with a borohydride-based reagent. This process may be used in the preparation of buprenorphine.
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