公开(公告)号：US20190216948A1

公开(公告)日：2019-07-18

申请号：US16245801

申请日：2019-01-11

Applicant: California Institute of Technology

Inventor： Yuki Oka ,  Vineet Augustine

IPC: A61K48/00 ,  A61P43/00 ,  A61K31/5513 ,  C12N7/00 ,  C12N15/86 ,  A61K38/17 ,  A61P13/12

CPC classification number: A61K48/005 ,  A61K31/5513 ,  A61K38/1787 ,  A61P13/12 ,  A61P43/00 ,  C12N7/00 ,  C12N15/86 ,  C12Y114/13039

Abstract: In some embodiments, methods of stimulating fluid intake in a subject in need thereof are described. The methods can comprise stimulating a nitric oxide synthase (nNOS)-positive neuron of the median preoptic nucleus (MnPO). In some embodiments, methods of inhibiting fluid intake in a subject in need thereof are described. The methods can comprise inhibiting stimulation of an nNOS-positive neuron of the MnPO.

公开(公告)号：US10960084B2

公开(公告)日：2021-03-30

申请号：US16245801

申请日：2019-01-11

Applicant: California Institute of Technology

Inventor： Yuki Oka ,  Vineet Augustine

IPC: A61K48/00 ,  A61P43/00 ,  A61K31/5513 ,  C12N15/86 ,  A61K38/17 ,  A61P13/12 ,  C12N7/00

Abstract: In some embodiments, methods of stimulating fluid intake in a subject in need thereof are described. The methods can comprise stimulating a nitric oxide synthase (nNOS)-positive neuron of the median preoptic nucleus (MnPO). In some embodiments, methods of inhibiting fluid intake in a subject in need thereof are described. The methods can comprise inhibiting stimulation of an nNOS-positive neuron of the MnPO.