专利检索 ap:("California Institute of Technology") AND inv:"Brian STOLTZ" 第 1 页

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发明申请
TOTAL SYNTHESIS OF PROSTAGLANDIN J NATURAL PRODUCTS BY TEREORETENTIVE METATHESIS 有权

公开(公告)号：US20210332011A1

公开(公告)日：2021-10-28

申请号：US17055970

申请日：2019-05-14

申请人： California Institute of Technology

发明人： Jiaming LI , Xu CHEN , Tonia S. AHMED , Brian STOLTZ , Robert H. GRUBBS

IPC分类号： C07C405/00 , B01J23/46

摘要： This invention relates generally to the synthesis of Δ12-Prostaglandin J product using stereoretentive ruthenium olefin metathesis catalysts supported by dithiolate ligands. Δ12-Prostaglandin J products were generated with excellent selectivity (>99% Z) and in moderate to high/good yields (47% to 80% yield; 58% to 80% yield).