公开(公告)号：US20210260119A1

公开(公告)日：2021-08-26

申请号：US17205951

申请日：2021-03-18

Applicant: CUROCELL INC. ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Chan Hyuk KIM ,  Young-Ho LEE ,  Yujean LEE ,  HyeongJi LEE ,  Sang Hoon LEE

IPC: A61K35/17 ,  A61P35/00 ,  A61K31/7088 ,  A61K38/17 ,  A61K39/395 ,  C07K14/725 ,  C07K14/705 ,  C07K16/28 ,  C12N15/113

Abstract: The present disclosure is broadly concerned with the field of cancer immunotherapy. For example, the present invention generally relates to an immune cell comprising a genetically engineered antigen receptor that specifically binds to a target antigen and a genetic disruption agent that reduces or is capable of reducing the expression in the immune cell of a gene that weakens the function of the immune cell.

公开(公告)号：US20210060067A1

公开(公告)日：2021-03-04

申请号：US16958649

申请日：2019-01-10

Applicant: CUROCELL INC. ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Chan Hyuk KIM ,  Young-Ho LEE ,  Yujean LEE ,  HyeongJi LEE ,  Sang Hoon LEE

IPC: A61K35/17 ,  A61P35/00 ,  C12N15/113 ,  A61K31/7088 ,  C07K16/28 ,  A61K39/395 ,  C07K14/705 ,  C07K14/725 ,  A61K38/17

Abstract: The present disclosure is broadly concerned with the field of cancer immunotherapy. For example, the present invention generally relates to an immune cell comprising a genetically engineered antigen receptor that specifically binds to a target antigen and a genetic disruption agent that reduces or is capable of reducing the expression in the immune cell of a gene that weakens the function of the immune cell.

公开(公告)号：US20230381236A1

公开(公告)日：2023-11-30

申请号：US18317797

申请日：2023-05-15

Applicant: CUROCELL, INC. ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Chan Hyuk KIM ,  Young-Ho LEE ,  Yujean LEE ,  HyeongJi LEE ,  Sang Hoon LEE

IPC: A61K35/17 ,  A61P35/00 ,  A61K31/7088 ,  A61K38/17 ,  A61K39/395 ,  C07K14/725 ,  C07K14/705 ,  C07K16/28 ,  C12N15/113 ,  C07K14/47 ,  C12N5/0783

CPC classification number: A61K35/17 ,  A61P35/00 ,  A61K31/7088 ,  A61K38/177 ,  A61K38/1774 ,  A61K39/3955 ,  A61K2039/505 ,  C07K14/70521 ,  C07K14/70578 ,  C07K16/2803 ,  C12N15/1138 ,  C07K14/4702 ,  C12N5/0637 ,  C07K14/7051

Abstract: The present disclosure is broadly concerned with the field of cancer immunotherapy. For example, the present invention generally relates to an immune cell comprising a genetically engineered antigen receptor that specifically binds to a target antigen and a genetic disruption agent that reduces or is capable of reducing the expression in the immune cell of a gene that weakens the function of the immune cell.

公开(公告)号：US20220348928A1

公开(公告)日：2022-11-03

申请号：US17626768

申请日：2020-07-16

Applicant: CUROCELL INC. ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Gun Soo KIM ,  Mi Kyung KIM ,  Chan Hyuk KIM ,  Young-Ho LEE ,  HyeongJi LEE

IPC: C12N15/113 ,  C07K14/725 ,  C07K14/705 ,  C07K16/28 ,  A61K35/17 ,  A61P35/00

Abstract: The present disclosure is broadly concerned with the field of cancer immunotherapy. For example, the present invention generally relates to an immune cell comprising a genetically engineered antigen receptor that specifically binds to a target antigen and a genetic disruption agent that reduces or is capable of reducing the expression in the immune cell of two genes that weaken the function of the immune cell.

公开(公告)号：US20220348871A1

公开(公告)日：2022-11-03

申请号：US17701535

申请日：2022-03-22

Applicant: CUROCELL INC. ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Chan Hyuk KIM ,  Young-Ho LEE ,  Yujean LEE ,  HyeongJi LEE ,  Sang Hoon LEE ,  Sang Hoon LEE

IPC: C12N5/0783 ,  C07K14/725 ,  C07K14/47

Abstract: The present disclosure is broadly concerned with the field of cancer immunotherapy. For example, the present invention generally relates to an immune cell comprising a genetically engineered antigen receptor that specifically binds to a target antigen and a genetic disruption agent that reduces or is capable of reducing the expression in the immune cell of a gene that weakens the function of the immune cell.