公开(公告)号：US20240268774A1

公开(公告)日：2024-08-15

申请号：US18612734

申请日：2024-03-21

申请人： Cleerly, Inc.

发明人： James K. Min ,  James P. Earls ,  Hugo Miguel Rodrigues Marques ,  Ben Hootnick

IPC分类号： A61B6/00 ,  A61B5/00 ,  A61B5/02 ,  A61B5/055 ,  A61B6/03 ,  A61B6/50 ,  A61B8/12 ,  A61B8/14 ,  A61K49/04 ,  G06F18/10 ,  G06T7/00 ,  G06V10/20 ,  G06V10/24 ,  G06V10/74 ,  G06V10/764 ,  G06V40/14

CPC分类号： A61B6/481 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/02007 ,  A61B5/055 ,  A61B5/7267 ,  A61B5/742 ,  A61B5/7475 ,  A61B6/032 ,  A61B6/037 ,  A61B6/504 ,  A61B6/5205 ,  A61B6/5217 ,  A61B8/12 ,  A61B8/14 ,  A61K49/04 ,  G06F18/10 ,  G06T7/0012 ,  G06V10/20 ,  G06V10/245 ,  G06V10/761 ,  G06V10/764 ,  G06V40/14 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10101 ,  G06T2207/10132 ,  G06T2207/20081 ,  G06T2207/30048 ,  G06T2207/30101 ,  G06V10/247

摘要： The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

公开(公告)号：US20240266064A1

公开(公告)日：2024-08-08

申请号：US18614586

申请日：2024-03-22

申请人： Cleerly, Inc.

发明人： James K. Min ,  James P. Earls ,  Shant Malkasian ,  Hugo Miguel Rodrigues Marques ,  Chung Chan ,  Shai Ronen

IPC分类号： G16H50/30 ,  A61B5/00 ,  A61B5/02 ,  G06T7/00 ,  G06T7/10 ,  G06T7/60 ,  G06V20/50 ,  G16H30/40

CPC分类号： G16H50/30 ,  A61B5/02028 ,  A61B5/4848 ,  G06T7/0016 ,  G06T7/10 ,  G06T7/60 ,  G06V20/50 ,  G16H30/40 ,  G06T2207/10048 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10101 ,  G06T2207/10104 ,  G06T2207/10108 ,  G06T2207/10116 ,  G06T2207/10132 ,  G06T2207/20081 ,  G06T2207/30048 ,  G06T2207/30101 ,  G06V2201/031

摘要： Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

公开(公告)号：US20240252130A1

公开(公告)日：2024-08-01

申请号：US18525434

申请日：2023-11-30

申请人： CLEERLY, INC.

发明人： James K. Min ,  James P. Earls ,  Hugo Miguel Rodrigues Marques

IPC分类号： A61B6/50 ,  A61B5/00 ,  A61B5/055 ,  A61B6/00 ,  A61B6/03 ,  A61B6/46 ,  A61B8/12 ,  A61B8/14 ,  A61K49/04 ,  G06F18/10 ,  G06T7/00 ,  G06V10/20 ,  G06V10/24 ,  G06V10/74 ,  G06V10/764 ,  G06V10/82

CPC分类号： A61B6/504 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/055 ,  A61B5/7267 ,  A61B5/742 ,  A61B5/7475 ,  A61B6/032 ,  A61B6/037 ,  A61B6/463 ,  A61B6/467 ,  A61B6/481 ,  A61B6/5205 ,  A61B8/12 ,  A61B8/14 ,  A61K49/04 ,  G06F18/10 ,  G06T7/0012 ,  G06V10/20 ,  G06V10/245 ,  G06V10/761 ,  G06V10/764 ,  G06V10/82 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10101 ,  G06T2207/10132 ,  G06T2207/20081 ,  G06T2207/30048 ,  G06T2207/30101 ,  G06V10/247

摘要： The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

公开(公告)号：US11969280B2

公开(公告)日：2024-04-30

申请号：US17350836

申请日：2021-06-17

申请人： CLEERLY, INC.

发明人： James K. Min ,  James P. Earls ,  Hugo Miguel Rodrigues Marques ,  Ben Hootnick

IPC分类号： A61B6/00 ,  A61B5/00 ,  A61B5/02 ,  A61B5/055 ,  A61B6/03 ,  A61B6/50 ,  A61B8/12 ,  A61B8/14 ,  A61K49/04 ,  G06F18/10 ,  G06T7/00 ,  G06V10/20 ,  G06V10/24 ,  G06V10/74 ,  G06V10/764 ,  G06V40/14

CPC分类号： A61B6/481 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/02007 ,  A61B5/055 ,  A61B5/7267 ,  A61B5/742 ,  A61B5/7475 ,  A61B6/032 ,  A61B6/037 ,  A61B6/504 ,  A61B6/5205 ,  A61B6/5217 ,  A61B8/12 ,  A61B8/14 ,  A61K49/04 ,  G06F18/10 ,  G06T7/0012 ,  G06V10/20 ,  G06V10/245 ,  G06V10/761 ,  G06V10/764 ,  G06V40/14 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10101 ,  G06T2207/10132 ,  G06T2207/20081 ,  G06T2207/30048 ,  G06T2207/30101 ,  G06V10/247

摘要： The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

公开(公告)号：US11922627B2

公开(公告)日：2024-03-05

申请号：US18454462

申请日：2023-08-23

申请人： Cleerly, Inc.

发明人： James K. Min ,  James P. Earls ,  Shant Malkasian ,  Hugo Miguel Rodrigues Marques ,  Chung Chan ,  Shai Ronen

IPC分类号： G06K9/00 ,  G06T7/00 ,  A61B5/00 ,  G06T7/62

CPC分类号： G06T7/0012 ,  A61B5/7275 ,  G06T7/62 ,  G06T2207/10048 ,  G06T2207/10081 ,  G06T2207/10101 ,  G06T2207/10104 ,  G06T2207/10108 ,  G06T2207/10116 ,  G06T2207/10132 ,  G06T2207/20081 ,  G06T2207/30101

摘要： Systems and methods of facilitating determination of risk of coronary artery disease (CAD) based at least in part on one or more measurements derived from non-invasive medical image analysis. The methods can include accessing a non-invasive generated medical image, identifying one or more arteries, identifying, regions of plaque within an artery, analyzing the regions of plaque to identify low density non-calcified plaque, non-calcified plaque, or calcified plaque based at least in part on density, determining a distance from identified regions of low density non-calcified plaque to one or more of a lumen wall or vessel wall, determining embeddedness of the regions of low density non-calcified plaque by one or more of non-calcified plaque or calcified plaque, determining a shape of the more regions of low density non-calcified plaque, and generating a display of the analysis to facilitate determination of one or more of a risk of CAD of the subject.

公开(公告)号：US20230401711A1

公开(公告)日：2023-12-14

申请号：US18456341

申请日：2023-08-25

申请人： Cleerly, Inc.

发明人： James K. Min ,  James P. Earls ,  Shant Malkasian ,  Hugo Miguel Rodrigues Marques ,  Chung Chan ,  Shai Ronen

IPC分类号： G06T7/00 ,  A61B5/00 ,  G06T7/62

CPC分类号： G06T7/0012 ,  A61B5/7275 ,  G06T7/62 ,  G06T2207/10108 ,  G06T2207/10101 ,  G06T2207/10081 ,  G06T2207/30101 ,  G06T2207/20081 ,  G06T2207/10104 ,  G06T2207/10116 ,  G06T2207/10048 ,  G06T2207/10132

摘要： Systems and methods of facilitating determination of risk of coronary artery disease (CAD) based at least in part on one or more measurements derived from non-invasive medical image analysis. The methods can include accessing a non-invasive generated medical image, identifying one or more arteries, identifying, regions of plaque within an artery, analyzing the regions of plaque to identify low density non-calcified plaque, non-calcified plaque, or calcified plaque based at least in part on density, determining a distance from identified regions of low density non-calcified plaque to one or more of a lumen wall or vessel wall, determining embeddedness of the regions of low density non-calcified plaque by one or more of non-calcified plaque or calcified plaque, determining a shape of the more regions of low density non-calcified plaque, and generating a display of the analysis to facilitate determination of one or more of a risk of CAD of the subject.

公开(公告)号：US11690586B2

公开(公告)日：2023-07-04

申请号：US18149021

申请日：2022-12-30

申请人： CLEERLY, INC.

发明人： James K. Min ,  James P. Earls ,  Hugo Miguel Rodrigues Marques ,  Ben Hootnick

IPC分类号： G06K9/00 ,  A61B6/00 ,  A61B8/14 ,  A61B6/03 ,  A61B5/00 ,  G06T7/00 ,  A61B8/12 ,  A61B5/055 ,  A61K49/04 ,  A61B5/02 ,  G06F18/10 ,  G06V10/74 ,  G06V10/764 ,  G06V10/20 ,  G06V10/24 ,  G06V40/14

CPC分类号： A61B6/481 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/02007 ,  A61B5/055 ,  A61B5/7267 ,  A61B5/742 ,  A61B5/7475 ,  A61B6/032 ,  A61B6/037 ,  A61B6/504 ,  A61B6/5205 ,  A61B6/5217 ,  A61B8/12 ,  A61B8/14 ,  A61K49/04 ,  G06F18/10 ,  G06T7/0012 ,  G06V10/20 ,  G06V10/245 ,  G06V10/761 ,  G06V10/764 ,  G06V40/14 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10101 ,  G06T2207/10132 ,  G06T2207/20081 ,  G06T2207/30048 ,  G06T2207/30101 ,  G06V10/247

摘要： The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

公开(公告)号：US20220392065A1

公开(公告)日：2022-12-08

申请号：US17820439

申请日：2022-08-17

申请人： CLEERLY, INC.

发明人： James K. Min ,  James P. Earls ,  Hugo Miguel Rodrigues Marques ,  Shant Malkasian ,  Ben Hootnick

IPC分类号： G06T7/00 ,  A61B8/14 ,  A61B6/00 ,  A61B6/03 ,  A61B5/00 ,  A61B8/12 ,  G06K9/62 ,  A61B5/055 ,  A61K49/04

摘要： The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, perform computational fluid dynamics analysis, facilitate assessment of risk of heart disease and coronary artery disease, enhance drug development, determine a CAD risk factor goal, provide atherosclerosis and vascular morphology characterization, and determine indication of myocardial risk, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

公开(公告)号：US20210366115A1

公开(公告)日：2021-11-25

申请号：US17394222

申请日：2021-08-04

申请人： CLEERLY, INC.

发明人： James K. Min ,  James P. Earls ,  Hugo Miguel Rodrigues Marques

IPC分类号： G06T7/00 ,  A61B5/055 ,  A61B6/03 ,  A61B8/14 ,  A61B8/12 ,  A61B5/00 ,  A61B6/00 ,  G06K9/62 ,  A61K49/04

摘要： The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

公开(公告)号：US11132796B2

公开(公告)日：2021-09-28

申请号：US17214593

申请日：2021-03-26

申请人： CLEERLY, INC.

发明人： James K. Min ,  James P. Earls ,  Hugo Miguel Rodrigues Marques

IPC分类号： G06K9/00 ,  G06T7/00 ,  A61B8/14 ,  A61B6/00 ,  A61B6/03 ,  A61B5/00 ,  A61B8/12 ,  G06K9/62 ,  A61B5/055 ,  A61K49/04

摘要： The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.